| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT2 | CREB1 | ENSPPYP00000011178 | ENSPPYP00000014658 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | CREB1 isoform 1. | 0.865 |
| AKT2 | CRTC2 | ENSPPYP00000011178 | ENSPPYP00000000929 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | CRTC2 isoform 3. | 0.919 |
| AKT2 | OGT | ENSPPYP00000011178 | ENSPPYP00000022902 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | OGT isoform 1. | 0.918 |
| AKT2 | PRKAA1 | ENSPPYP00000011178 | ENSPPYP00000017227 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] | 0.527 |
| AKT2 | PRKAA2 | ENSPPYP00000011178 | ENSPPYP00000001519 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] | 0.505 |
| CREB1 | AKT2 | ENSPPYP00000014658 | ENSPPYP00000011178 | CREB1 isoform 1. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.865 |
| CREB1 | CRTC2 | ENSPPYP00000014658 | ENSPPYP00000000929 | CREB1 isoform 1. | CRTC2 isoform 3. | 0.992 |
| CREB1 | SIK2 | ENSPPYP00000014658 | ENSPPYP00000004424 | CREB1 isoform 1. | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (By similarity). | 0.452 |
| CRTC2 | AKT2 | ENSPPYP00000000929 | ENSPPYP00000011178 | CRTC2 isoform 3. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.919 |
| CRTC2 | CREB1 | ENSPPYP00000000929 | ENSPPYP00000014658 | CRTC2 isoform 3. | CREB1 isoform 1. | 0.992 |
| CRTC2 | OGT | ENSPPYP00000000929 | ENSPPYP00000022902 | CRTC2 isoform 3. | OGT isoform 1. | 0.942 |
| CRTC2 | PPP3CA | ENSPPYP00000000929 | ENSPPYP00000016705 | CRTC2 isoform 3. | Serine/threonine-protein phosphatase. | 0.933 |
| CRTC2 | PPP3CB | ENSPPYP00000000929 | ENSPPYP00000002711 | CRTC2 isoform 3. | Serine/threonine-protein phosphatase. | 0.933 |
| CRTC2 | PPP3CC | ENSPPYP00000000929 | ENSPPYP00000020644 | CRTC2 isoform 3. | Serine/threonine-protein phosphatase. | 0.957 |
| CRTC2 | PRKAA1 | ENSPPYP00000000929 | ENSPPYP00000017227 | CRTC2 isoform 3. | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] | 0.926 |
| CRTC2 | PRKAA2 | ENSPPYP00000000929 | ENSPPYP00000001519 | CRTC2 isoform 3. | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] | 0.925 |
| CRTC2 | SIK1 | ENSPPYP00000000929 | ENSPPYP00000012803 | CRTC2 isoform 3. | SIK1 isoform 1. | 0.961 |
| CRTC2 | SIK2 | ENSPPYP00000000929 | ENSPPYP00000004424 | CRTC2 isoform 3. | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (By similarity). | 0.987 |
| OGT | AKT2 | ENSPPYP00000022902 | ENSPPYP00000011178 | OGT isoform 1. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.918 |
| OGT | CRTC2 | ENSPPYP00000022902 | ENSPPYP00000000929 | OGT isoform 1. | CRTC2 isoform 3. | 0.942 |
