Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
POGZPogo transposable element derived with ZNF domain. (1410 aa)    
Predicted Functional Partners:
CBX3
Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...]
   
 0.903
CBX5
CBX5 isoform 2.
   
 0.896
CBX1
CBX1 isoform 1.
   
 0.870
ENSPPYP00000016983
annotation not available
   
 0.870
CHAMP1
Chromosome alignment maintaining phosphoprotein 1.
   
 
 0.868
PSIP1
PC4 and SFRS1 interacting protein 1.
   
 
 0.867
MAD2L2
Mitotic arrest deficient 2 like 2.
    
 
 0.806
EHMT2
EHMT2 isoform 5.
   
 0.714
CHD4
CHD4 isoform 1.
   
 0.681
CR201_G0044328
HDGFL2 isoform 2.
   
 
 0.674
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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