Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ZNF687Zinc finger protein 687. (1236 aa)    
Predicted Functional Partners:
ZMYND8
ZMYND8 isoform 16.
   
 
 0.968
INTS3
Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
   
   0.920
INTS1
INTS1 isoform 1.
   
   0.920
INTS5
Integrator complex subunit 5.
   
   0.919
ZNF592
ZNF592 isoform 1.
   
 
 0.859
TSPYL2
TSPYL2 isoform 1; Belongs to the nucleosome assembly protein (NAP) family.
    
 
 0.822
UBE2O
Ubiquitin conjugating enzyme E2 O.
   
  0.794
CSNK2A2
CSNK2A2 isoform 1; Belongs to the protein kinase superfamily.
    
 
 0.790
INTS6
INTS6 isoform 5.
    
   0.762
ENSPPYP00000017224
annotation not available
    
   0.762
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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