STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEMA6CSEMA6C isoform 1; Belongs to the semaphorin family. (932 aa)    
Predicted Functional Partners:
SEMA6A
SEMA6A isoform 1; Belongs to the semaphorin family.
     
0.903
PLXNA1
PLXNA1 isoform 1.
    
 0.803
PLXNA2
PLXNA2 isoform 1.
    
 0.725
PLXNA4
PLXNA4 isoform 2.
    
 0.710
CD19
CD19 isoform 3.
      
 0.704
PLXNA3
PLXNA3 isoform 1.
    
 0.689
PLXND1
PLXND1 isoform 1.
    
 0.684
PLXNC1
PLXNC1 isoform 1.
    
 0.656
MST1R
MST1R isoform 1.
    
 0.617
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.617
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: medium (54%) [HD]