Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SEMA6CSEMA6C isoform 1; Belongs to the semaphorin family. (932 aa)    
Predicted Functional Partners:
PLXNA3
PLXNA3 isoform 1.
    
 0.705
SAP18
Histone deacetylase complex subunit SAP18; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or durin [...]
      
 0.658
CCNB3
CCNB3 isoform 3; Belongs to the cyclin family.
      
 0.646
PLXNA2
PLXNA2 isoform 1.
    
 0.639
NRP1
Neuropilin; Belongs to the neuropilin family.
    
 0.636
CD19
CD19 isoform 3.
      
 0.621
PLXNA4
PLXNA4 isoform 2.
    
 0.598
PLXNA1
PLXNA1 isoform 1.
    
 0.594
PLXND1
PLXND1 isoform 1.
    
 0.552
PLXNC1
PLXNC1 isoform 1.
    
 0.544
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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