Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VPS45Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)    
Predicted Functional Partners:
RBSN
Rabenosyn, RAB effector.
    
 0.999
STX16
STX16-NPEPL1 isoform 1; Belongs to the syntaxin family.
    
 
 0.954
VTI1A
Vesicle transport through interaction with t-SNAREs 1A.
   
 
 0.928
STX6
Syntaxin-6; Involved in intracellular vesicle trafficking.
    
 
 0.927
ERGIC3
Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi.
 
      0.899
COG4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
   
 
 0.893
RAB5A
RAB5A, member RAS oncogene family.
    
 0.886
VPS18
VPS18 core subunit of CORVET and HOPS complexes.
    
 0.883
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
    
 0.877
STX10
STX10 isoform 6; Belongs to the syntaxin family.
    
 
 0.861
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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