Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)    
Predicted Functional Partners:
HIST2H2BE
Histone H2B; Belongs to the histone H2B family.
  
 0.992
H2AC6
Histone H2A; Belongs to the histone H2A family.
   
  0.989
H2AJ
Histone H2A; Belongs to the histone H2A family.
   
  0.987
ENSPPYP00000004532
annotation not available
   
  0.986
H2AC21
Histone H2A; Belongs to the histone H2A family.
   
  0.984
H2AC1
Histone H2A; Belongs to the histone H2A family.
   
  0.982
RNF2
E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...]
    
 0.972
H2BC18
Histone H2B; Belongs to the histone H2B family.
  
 0.972
LOC100456589
Histone H2B; Belongs to the histone H2B family.
  
 0.960
H2BC5
Histone H2B; Belongs to the histone H2B family.
  
 0.953
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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