ENSPPYP00000001072 protein (Pongo abelii) - STRING interaction network

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Score

ENSPPYP00000001072

annotation not available (77 aa)

Predicted Functional Partners:

H4C7

0.760

MYSM1

0.740

H2BC14

0.666

ATM

0.566

KAT2B

0.537

HIST2H2BE

0.535

TP53BP1

0.535

H2BC1

0.535

H2BC3

0.535

H2BC5

0.535

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ENSPPYP00000001072	ENSPPYP00000004403	ENSPPYP00000001072	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.566
ATM	H4C7	ENSPPYP00000004403	ENSPPYP00000018250	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.804
ATM	HIST2H2BE	ENSPPYP00000004403	ENSPPYP00000001071	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H2B; Belongs to the histone H2B family.	0.451
ATM	MYSM1	ENSPPYP00000004403	ENSPPYP00000001512	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MYSM1 isoform 1.	0.435
ATM	TP53BP1	ENSPPYP00000004403	ENSPPYP00000007267	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TP53BP1 isoform 3.	0.993
ENSPPYP00000001072	ATM	ENSPPYP00000001072	ENSPPYP00000004403	annotation not available	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.566
ENSPPYP00000001072	H2BC1	ENSPPYP00000001072	ENSPPYP00000018220	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.535
ENSPPYP00000001072	H2BC14	ENSPPYP00000001072	ENSPPYP00000018278	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.666
ENSPPYP00000001072	H2BC3	ENSPPYP00000001072	ENSPPYP00000018231	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.535
ENSPPYP00000001072	H2BC5	ENSPPYP00000001072	ENSPPYP00000018240	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.535
ENSPPYP00000001072	H4C7	ENSPPYP00000001072	ENSPPYP00000018250	annotation not available	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.760
ENSPPYP00000001072	HIST2H2BE	ENSPPYP00000001072	ENSPPYP00000001071	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.535
ENSPPYP00000001072	KAT2B	ENSPPYP00000001072	ENSPPYP00000015742	annotation not available	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.537
ENSPPYP00000001072	MYSM1	ENSPPYP00000001072	ENSPPYP00000001512	annotation not available	MYSM1 isoform 1.	0.740
ENSPPYP00000001072	TP53BP1	ENSPPYP00000001072	ENSPPYP00000007267	annotation not available	TP53BP1 isoform 3.	0.535
H2BC1	ENSPPYP00000001072	ENSPPYP00000018220	ENSPPYP00000001072	Histone H2B; Belongs to the histone H2B family.	annotation not available	0.535
H2BC1	H2BC14	ENSPPYP00000018220	ENSPPYP00000018278	Histone H2B; Belongs to the histone H2B family.	Histone H2B; Belongs to the histone H2B family.	0.947
H2BC1	H2BC3	ENSPPYP00000018220	ENSPPYP00000018231	Histone H2B; Belongs to the histone H2B family.	Histone H2B; Belongs to the histone H2B family.	0.969
H2BC1	H2BC5	ENSPPYP00000018220	ENSPPYP00000018240	Histone H2B; Belongs to the histone H2B family.	Histone H2B; Belongs to the histone H2B family.	0.960
H2BC1	H4C7	ENSPPYP00000018220	ENSPPYP00000018250	Histone H2B; Belongs to the histone H2B family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.776