node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT | DMGDH | ENSPPYP00000014927 | ENSPPYP00000017421 | Serine--pyruvate aminotransferase. | DMGDH isoform 5. | 0.539 |
AGXT | GLDC | ENSPPYP00000014927 | ENSPPYP00000021533 | Serine--pyruvate aminotransferase. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.507 |
AGXT | PHGDH | ENSPPYP00000014927 | ENSPPYP00000001120 | Serine--pyruvate aminotransferase. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.752 |
AGXT | PSAT1 | ENSPPYP00000014927 | ENSPPYP00000021636 | Serine--pyruvate aminotransferase. | Phosphoserine aminotransferase. | 0.450 |
ALDH18A1 | BPGM | ENSPPYP00000002911 | ENSPPYP00000020217 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.409 |
ALDH18A1 | GLDC | ENSPPYP00000002911 | ENSPPYP00000021533 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.551 |
ALDH18A1 | PGAM1 | ENSPPYP00000002911 | ENSPPYP00000002936 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. | 0.409 |
ALDH18A1 | PGAM2 | ENSPPYP00000002911 | ENSPPYP00000019725 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.409 |
ALDH18A1 | PHGDH | ENSPPYP00000002911 | ENSPPYP00000001120 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.718 |
ALDH18A1 | PSAT1 | ENSPPYP00000002911 | ENSPPYP00000021636 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Phosphoserine aminotransferase. | 0.802 |
BPGM | ALDH18A1 | ENSPPYP00000020217 | ENSPPYP00000002911 | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.409 |
BPGM | PGAM1 | ENSPPYP00000020217 | ENSPPYP00000002936 | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. | 0.938 |
BPGM | PGAM2 | ENSPPYP00000020217 | ENSPPYP00000019725 | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | 0.948 |
BPGM | PHGDH | ENSPPYP00000020217 | ENSPPYP00000001120 | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.910 |
CC2D1B | H2AZ1 | ENSPPYP00000001569 | ENSPPYP00000016702 | CC2D1B isoform 4. | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] | 0.854 |
CC2D1B | PHGDH | ENSPPYP00000001569 | ENSPPYP00000001120 | CC2D1B isoform 4. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.874 |
DMGDH | AGXT | ENSPPYP00000017421 | ENSPPYP00000014927 | DMGDH isoform 5. | Serine--pyruvate aminotransferase. | 0.539 |
DMGDH | GLDC | ENSPPYP00000017421 | ENSPPYP00000021533 | DMGDH isoform 5. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
DMGDH | PHGDH | ENSPPYP00000017421 | ENSPPYP00000001120 | DMGDH isoform 5. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.739 |
DMGDH | PSAT1 | ENSPPYP00000017421 | ENSPPYP00000021636 | DMGDH isoform 5. | Phosphoserine aminotransferase. | 0.668 |