ENSPPYP00000001123 protein (Pongo abelii) - STRING interaction network

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Score

ENSPPYP00000001123

annotation not available (168 aa)

Predicted Functional Partners:

HSD17B7

0.711

CR201_G0031384

0.698

FAU

0.698

CYP51A1

0.692

SQLE

0.679

FDFT1

0.677

CH25H

0.662

MSMO1

0.662

SC5D

0.659

LSS

0.645

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CH25H	CYP51A1	ENSPPYP00000002851	ENSPPYP00000019976	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	0.962
CH25H	ENSPPYP00000001123	ENSPPYP00000002851	ENSPPYP00000001123	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	annotation not available	0.662
CH25H	FDFT1	ENSPPYP00000002851	ENSPPYP00000020559	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family.	0.814
CH25H	HSD17B7	ENSPPYP00000002851	ENSPPYP00000000676	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	HSD17B7 isoform 2.	0.842
CH25H	LSS	ENSPPYP00000002851	ENSPPYP00000012870	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.748
CH25H	SC5D	ENSPPYP00000002851	ENSPPYP00000004558	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	Sterol-C5-desaturase; Belongs to the sterol desaturase family.	0.905
CH25H	SQLE	ENSPPYP00000002851	ENSPPYP00000021174	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	SQLE isoform 1.	0.949
CR201_G0031384	ENSPPYP00000001123	ENSPPYP00000003548	ENSPPYP00000001123	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	annotation not available	0.698
CR201_G0031384	FAU	ENSPPYP00000003548	ENSPPYP00000003561	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ubiquitin-like protein FUBI.	0.882
CYP51A1	CH25H	ENSPPYP00000019976	ENSPPYP00000002851	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	0.962
CYP51A1	ENSPPYP00000001123	ENSPPYP00000019976	ENSPPYP00000001123	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	annotation not available	0.692
CYP51A1	FDFT1	ENSPPYP00000019976	ENSPPYP00000020559	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family.	0.936
CYP51A1	HSD17B7	ENSPPYP00000019976	ENSPPYP00000000676	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	HSD17B7 isoform 2.	0.907
CYP51A1	LSS	ENSPPYP00000019976	ENSPPYP00000012870	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.997
CYP51A1	MSMO1	ENSPPYP00000019976	ENSPPYP00000016960	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.	0.979
CYP51A1	SC5D	ENSPPYP00000019976	ENSPPYP00000004558	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	Sterol-C5-desaturase; Belongs to the sterol desaturase family.	0.942
CYP51A1	SQLE	ENSPPYP00000019976	ENSPPYP00000021174	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	SQLE isoform 1.	0.981
ENSPPYP00000001123	CH25H	ENSPPYP00000001123	ENSPPYP00000002851	annotation not available	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.	0.662
ENSPPYP00000001123	CR201_G0031384	ENSPPYP00000001123	ENSPPYP00000003548	annotation not available	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.698
ENSPPYP00000001123	CYP51A1	ENSPPYP00000001123	ENSPPYP00000019976	annotation not available	Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...]	0.692