HSD3B1 protein (Pongo abelii) - STRING interaction network

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HSD3B1

HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. (375 aa)

Predicted Functional Partners:

CYP17A1

0.979

CR201_G0028793

0.977

CYP19A1

0.962

CYP7B1

0.955

HSD17B3

0.954

CYP21A2

0.953

SRD5A1

0.945

CYP7A1

0.945

CYP11B1

0.944

SRD5A3

0.936

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0028793	CYP17A1	ENSPPYP00000007772	ENSPPYP00000003038	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	0.950
CR201_G0028793	CYP19A1	ENSPPYP00000007772	ENSPPYP00000007338	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.621
CR201_G0028793	CYP21A2	ENSPPYP00000007772	ENSPPYP00000018425	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	CYP21A2 isoform 1; Belongs to the cytochrome P450 family.	0.948
CR201_G0028793	CYP7A1	ENSPPYP00000007772	ENSPPYP00000020869	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.454
CR201_G0028793	CYP7B1	ENSPPYP00000007772	ENSPPYP00000020894	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.970
CR201_G0028793	HSD17B3	ENSPPYP00000007772	ENSPPYP00000021754	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.605
CR201_G0028793	HSD3B1	ENSPPYP00000007772	ENSPPYP00000001124	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	HSD3B1 isoform 1; Belongs to the 3-beta-HSD family.	0.977
CR201_G0028793	SRD5A1	ENSPPYP00000007772	ENSPPYP00000017128	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).	0.508
CYP11B1	CYP17A1	ENSPPYP00000021229	ENSPPYP00000003038	CYP11B2 isoform 1.	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	0.949
CYP11B1	CYP19A1	ENSPPYP00000021229	ENSPPYP00000007338	CYP11B2 isoform 1.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.937
CYP11B1	CYP21A2	ENSPPYP00000021229	ENSPPYP00000018425	CYP11B2 isoform 1.	CYP21A2 isoform 1; Belongs to the cytochrome P450 family.	0.954
CYP11B1	CYP7B1	ENSPPYP00000021229	ENSPPYP00000020894	CYP11B2 isoform 1.	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.512
CYP11B1	HSD17B3	ENSPPYP00000021229	ENSPPYP00000021754	CYP11B2 isoform 1.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.942
CYP11B1	HSD3B1	ENSPPYP00000021229	ENSPPYP00000001124	CYP11B2 isoform 1.	HSD3B1 isoform 1; Belongs to the 3-beta-HSD family.	0.944
CYP11B1	SRD5A1	ENSPPYP00000021229	ENSPPYP00000017128	CYP11B2 isoform 1.	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).	0.925
CYP11B1	SRD5A3	ENSPPYP00000021229	ENSPPYP00000016490	CYP11B2 isoform 1.	Steroid 5 alpha-reductase 3.	0.928
CYP17A1	CR201_G0028793	ENSPPYP00000003038	ENSPPYP00000007772	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.950
CYP17A1	CYP11B1	ENSPPYP00000003038	ENSPPYP00000021229	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	CYP11B2 isoform 1.	0.949
CYP17A1	CYP19A1	ENSPPYP00000003038	ENSPPYP00000007338	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.953
CYP17A1	CYP21A2	ENSPPYP00000003038	ENSPPYP00000018425	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	CYP21A2 isoform 1; Belongs to the cytochrome P450 family.	0.928