HSD3B1 protein (Pongo abelii) - STRING interaction network

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Score

HSD3B1

HSD3B1 isoform 1; Belongs to the 3-beta-HSD family. (375 aa)

Predicted Functional Partners:

CR201_G0028793

0.985

CYP17A1

0.982

CYP19A1

0.972

HSD17B3

0.963

CYP21A2

0.962

CYP11B2

0.962

CYP7B1

0.955

SRD5A1

0.953

CYP7A1

0.946

HSD17B2

0.944

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0028793	CYP17A1	ENSPPYP00000007772	ENSPPYP00000003038	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	0.951
CR201_G0028793	CYP19A1	ENSPPYP00000007772	ENSPPYP00000007338	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.649
CR201_G0028793	CYP21A2	ENSPPYP00000007772	ENSPPYP00000018425	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	CYP21A2 isoform 1; Belongs to the cytochrome P450 family.	0.948
CR201_G0028793	CYP7A1	ENSPPYP00000007772	ENSPPYP00000020869	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.438
CR201_G0028793	CYP7B1	ENSPPYP00000007772	ENSPPYP00000020894	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.960
CR201_G0028793	HSD17B2	ENSPPYP00000007772	ENSPPYP00000008566	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.400
CR201_G0028793	HSD17B3	ENSPPYP00000007772	ENSPPYP00000021754	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.650
CR201_G0028793	HSD3B1	ENSPPYP00000007772	ENSPPYP00000001124	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	HSD3B1 isoform 1; Belongs to the 3-beta-HSD family.	0.985
CR201_G0028793	SRD5A1	ENSPPYP00000007772	ENSPPYP00000017128	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).	0.581
CYP11B2	CYP17A1	ENSPPYP00000021230	ENSPPYP00000003038	Cytochrome P450 11B2, mitochondrial isoform X1.	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	0.946
CYP11B2	CYP19A1	ENSPPYP00000021230	ENSPPYP00000007338	Cytochrome P450 11B2, mitochondrial isoform X1.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.931
CYP11B2	CYP21A2	ENSPPYP00000021230	ENSPPYP00000018425	Cytochrome P450 11B2, mitochondrial isoform X1.	CYP21A2 isoform 1; Belongs to the cytochrome P450 family.	0.956
CYP11B2	CYP7B1	ENSPPYP00000021230	ENSPPYP00000020894	Cytochrome P450 11B2, mitochondrial isoform X1.	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.542
CYP11B2	HSD17B2	ENSPPYP00000021230	ENSPPYP00000008566	Cytochrome P450 11B2, mitochondrial isoform X1.	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.915
CYP11B2	HSD17B3	ENSPPYP00000021230	ENSPPYP00000021754	Cytochrome P450 11B2, mitochondrial isoform X1.	Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.945
CYP11B2	HSD3B1	ENSPPYP00000021230	ENSPPYP00000001124	Cytochrome P450 11B2, mitochondrial isoform X1.	HSD3B1 isoform 1; Belongs to the 3-beta-HSD family.	0.962
CYP11B2	SRD5A1	ENSPPYP00000021230	ENSPPYP00000017128	Cytochrome P450 11B2, mitochondrial isoform X1.	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)).	0.922
CYP17A1	CR201_G0028793	ENSPPYP00000003038	ENSPPYP00000007772	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.951
CYP17A1	CYP11B2	ENSPPYP00000003038	ENSPPYP00000021230	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	Cytochrome P450 11B2, mitochondrial isoform X1.	0.946
CYP17A1	CYP19A1	ENSPPYP00000003038	ENSPPYP00000007338	CYP17A1 isoform 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.958