Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VTCN1VTCN1 isoform 1. (191 aa)    
Predicted Functional Partners:
BTLA
B and T lymphocyte associated.
      
 0.632
PDCD1LG2
PDCD1LG2 isoform 1.
   
  
 0.630
CHMP3
Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...]
      
 0.617
GABRP
GABRP isoform 5; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.590
ICOS
ICOS isoform 1.
    
 0.574
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
      
 0.568
CEACAM19
CEACAM19 isoform 7.
      
 0.537
HELZ2
HELZ2 isoform 3.
    
 0.531
CR201_G0049429
PDCD1 isoform 1.
    
 
 0.520
CR201_G0025591
TNFRSF14 isoform 6.
     
 0.497
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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