Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VANGL1Vang-like protein. (524 aa)    
Predicted Functional Partners:
DVL1
DVL1 isoform 2.
    
 0.984
PRICKLE2
PRICKLE2 isoform 2.
    
 0.981
PRICKLE1
Prickle planar cell polarity protein 1.
    
 0.980
TOMM6
Mitochondrial import receptor subunit TOM6 homolog isoform X2.
    
 0.979
DVL2
DVL2 isoform 1.
    
 0.974
DVL3
DVL3 isoform 1.
    
 0.971
VANGL2
Vang-like protein.
  
 
0.963
ODAM
ODAM isoform 1.
      
 0.852
CELSR1
CELSR1 isoform 1; Belongs to the G-protein coupled receptor 2 family.
    
 0.790
FZD6
Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]
   
 0.787
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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