NGF protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

NGF

NGF isoform 1; Belongs to the NGF-beta family. (294 aa)

Predicted Functional Partners:

NGFR

0.999

NTRK1

0.998

NTRK3

0.977

NTRK2

0.971

SORT1

0.891

BDNF

0.877

SORCS2

0.871

CNTF

0.822

IGF1R

0.725

NSF

0.723

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	CNTF	ENSPPYP00000003904	ENSPPYP00000024682	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	CNTF isoform 1.	0.840
BDNF	IGF1R	ENSPPYP00000003904	ENSPPYP00000007720	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.756
BDNF	NGF	ENSPPYP00000003904	ENSPPYP00000001154	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	NGF isoform 1; Belongs to the NGF-beta family.	0.877
BDNF	NGFR	ENSPPYP00000003904	ENSPPYP00000010010	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	NGFR isoform 1.	0.974
BDNF	NTRK1	ENSPPYP00000003904	ENSPPYP00000000808	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.974
BDNF	NTRK2	ENSPPYP00000003904	ENSPPYP00000021662	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.999
BDNF	NTRK3	ENSPPYP00000003904	ENSPPYP00000007657	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Tyrosine-protein kinase receptor.	0.911
BDNF	SORCS2	ENSPPYP00000003904	ENSPPYP00000016280	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	SORCS2 isoform 3.	0.434
BDNF	SORT1	ENSPPYP00000003904	ENSPPYP00000001248	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Sortilin.	0.893
CNTF	BDNF	ENSPPYP00000024682	ENSPPYP00000003904	CNTF isoform 1.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.840
CNTF	NGF	ENSPPYP00000024682	ENSPPYP00000001154	CNTF isoform 1.	NGF isoform 1; Belongs to the NGF-beta family.	0.822
IGF1R	BDNF	ENSPPYP00000007720	ENSPPYP00000003904	Tyrosine-protein kinase receptor.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.756
IGF1R	NGF	ENSPPYP00000007720	ENSPPYP00000001154	Tyrosine-protein kinase receptor.	NGF isoform 1; Belongs to the NGF-beta family.	0.725
NGF	BDNF	ENSPPYP00000001154	ENSPPYP00000003904	NGF isoform 1; Belongs to the NGF-beta family.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.877
NGF	CNTF	ENSPPYP00000001154	ENSPPYP00000024682	NGF isoform 1; Belongs to the NGF-beta family.	CNTF isoform 1.	0.822
NGF	IGF1R	ENSPPYP00000001154	ENSPPYP00000007720	NGF isoform 1; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.725
NGF	NGFR	ENSPPYP00000001154	ENSPPYP00000010010	NGF isoform 1; Belongs to the NGF-beta family.	NGFR isoform 1.	0.999
NGF	NSF	ENSPPYP00000001154	ENSPPYP00000009318	NGF isoform 1; Belongs to the NGF-beta family.	Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity); Belongs to the AAA ATPase family.	0.723
NGF	NTRK1	ENSPPYP00000001154	ENSPPYP00000000808	NGF isoform 1; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.998
NGF	NTRK2	ENSPPYP00000001154	ENSPPYP00000021662	NGF isoform 1; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.971