TSHB protein (Pongo abelii) - STRING interaction network

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Score

TSHB

Thyroid stimulating hormone subunit beta. (138 aa)

Predicted Functional Partners:

TSHR

0.995

CGA

0.991

FSHR

0.925

LHCGR

0.898

GNB1

0.825

GNG2

0.808

PRL

0.775

POU1F1

0.769

ENSPPYP00000012086

0.763

TMEM189-UBE2V1

0.763

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CGA	FSHR	ENSPPYP00000018835	ENSPPYP00000013860	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	0.911
CGA	GNB1	ENSPPYP00000018835	ENSPPYP00000002307	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.800
CGA	GNG2	ENSPPYP00000018835	ENSPPYP00000006605	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).	0.800
CGA	LHCGR	ENSPPYP00000018835	ENSPPYP00000013861	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.910
CGA	TSHB	ENSPPYP00000018835	ENSPPYP00000001157	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Thyroid stimulating hormone subunit beta.	0.991
CGA	TSHR	ENSPPYP00000018835	ENSPPYP00000006869	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.913
ENSPPYP00000012086	TMEM189-UBE2V1	ENSPPYP00000012086	ENSPPYP00000012429	annotation not available	Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...]	0.981
ENSPPYP00000012086	TSHB	ENSPPYP00000012086	ENSPPYP00000001157	annotation not available	Thyroid stimulating hormone subunit beta.	0.763
FSHR	CGA	ENSPPYP00000013860	ENSPPYP00000018835	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.911
FSHR	GNB1	ENSPPYP00000013860	ENSPPYP00000002307	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.976
FSHR	GNG2	ENSPPYP00000013860	ENSPPYP00000006605	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).	0.908
FSHR	PRL	ENSPPYP00000013860	ENSPPYP00000018197	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	PRL isoform 1.	0.599
FSHR	TSHB	ENSPPYP00000013860	ENSPPYP00000001157	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	Thyroid stimulating hormone subunit beta.	0.925
GNB1	CGA	ENSPPYP00000002307	ENSPPYP00000018835	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.800
GNB1	FSHR	ENSPPYP00000002307	ENSPPYP00000013860	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	0.976
GNB1	GNG2	ENSPPYP00000002307	ENSPPYP00000006605	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).	0.947
GNB1	LHCGR	ENSPPYP00000002307	ENSPPYP00000013861	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.976
GNB1	TSHB	ENSPPYP00000002307	ENSPPYP00000001157	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Thyroid stimulating hormone subunit beta.	0.825
GNB1	TSHR	ENSPPYP00000002307	ENSPPYP00000006869	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.933
GNG2	CGA	ENSPPYP00000006605	ENSPPYP00000018835	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.800