node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADORA2A | CGA | ENSPPYP00000012991 | ENSPPYP00000018835 | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | 0.650 |
ADORA2A | GNAS | ENSPPYP00000012991 | ENSPPYP00000012485 | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | GNAS isoform 2. | 0.993 |
ADORA2A | GNB1 | ENSPPYP00000012991 | ENSPPYP00000002307 | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.909 |
ADORA2A | TSHB | ENSPPYP00000012991 | ENSPPYP00000001157 | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | Thyroid stimulating hormone subunit beta. | 0.759 |
CGA | ADORA2A | ENSPPYP00000018835 | ENSPPYP00000012991 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | 0.650 |
CGA | FSHR | ENSPPYP00000018835 | ENSPPYP00000013860 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.908 |
CGA | LHCGR | ENSPPYP00000018835 | ENSPPYP00000013861 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.905 |
CGA | TSHB | ENSPPYP00000018835 | ENSPPYP00000001157 | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | Thyroid stimulating hormone subunit beta. | 0.914 |
FANCA | TSHB | ENSPPYP00000008650 | ENSPPYP00000001157 | FANCA isoform 6. | Thyroid stimulating hormone subunit beta. | 0.821 |
FSHR | CGA | ENSPPYP00000013860 | ENSPPYP00000018835 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. | 0.908 |
FSHR | GNAS | ENSPPYP00000013860 | ENSPPYP00000012485 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | GNAS isoform 2. | 0.954 |
FSHR | LHCGR | ENSPPYP00000013860 | ENSPPYP00000013861 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.445 |
FSHR | PRL | ENSPPYP00000013860 | ENSPPYP00000018197 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | PRL isoform 1. | 0.485 |
FSHR | TSHB | ENSPPYP00000013860 | ENSPPYP00000001157 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Thyroid stimulating hormone subunit beta. | 0.925 |
GNAS | ADORA2A | ENSPPYP00000012485 | ENSPPYP00000012991 | GNAS isoform 2. | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. | 0.993 |
GNAS | FSHR | ENSPPYP00000012485 | ENSPPYP00000013860 | GNAS isoform 2. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.954 |
GNAS | GNB1 | ENSPPYP00000012485 | ENSPPYP00000002307 | GNAS isoform 2. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.997 |
GNAS | LHCGR | ENSPPYP00000012485 | ENSPPYP00000013861 | GNAS isoform 2. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.963 |
GNAS | TSHB | ENSPPYP00000012485 | ENSPPYP00000001157 | GNAS isoform 2. | Thyroid stimulating hormone subunit beta. | 0.877 |
GNAS | TSHR | ENSPPYP00000012485 | ENSPPYP00000006869 | GNAS isoform 2. | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.961 |