Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
SIKE1Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). (207 aa)    
Predicted Functional Partners:
STRIP1
Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity); Belongs to the STRIP family.
    
 0.996
MOB4
MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions.
    
 0.982
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.972
STRN4
STRN4 isoform 4.
    
 0.969
PDCD10
PDCD10 isoform 1.
   
 0.968
SLMAP
SLMAP isoform 6.
    
 
 0.963
STRIP2
STRIP2 isoform 1.
    
 0.962
STRN
STRN isoform 1.
    
 0.959
CTTNBP2NL
CTTNBP2 N-terminal-like protein.
     
 0.956
STRN3
STRN3 isoform 2.
    
 0.956
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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