SYT6 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

SYT6

SYT6 isoform 1. (509 aa)

Predicted Functional Partners:

SYT10

0.802

SYT3

0.790

MADD

0.766

PGLYRP4

0.716

DRD2

0.635

STON2

0.596

PGLYRP3

0.533

LAMP5

0.520

SYT9

0.513

ZP4

0.498

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DRD2	STON2	ENSPPYP00000004451	ENSPPYP00000006872	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	STON2 isoform 2; Belongs to the Stoned B family.	0.447
DRD2	SYT10	ENSPPYP00000004451	ENSPPYP00000005031	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity); Belongs to the synaptotagmin family.	0.431
DRD2	SYT3	ENSPPYP00000004451	ENSPPYP00000011519	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	Synaptotagmin 3.	0.418
DRD2	SYT6	ENSPPYP00000004451	ENSPPYP00000001170	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	SYT6 isoform 1.	0.635
LAMP5	SYT10	ENSPPYP00000011964	ENSPPYP00000005031	Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain; Belongs to the LAMP family.	Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity); Belongs to the synaptotagmin family.	0.432
LAMP5	SYT6	ENSPPYP00000011964	ENSPPYP00000001170	Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain; Belongs to the LAMP family.	SYT6 isoform 1.	0.520
MADD	SYT10	ENSPPYP00000003795	ENSPPYP00000005031	MADD isoform 6.	Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity); Belongs to the synaptotagmin family.	0.411
MADD	SYT3	ENSPPYP00000003795	ENSPPYP00000011519	MADD isoform 6.	Synaptotagmin 3.	0.546
MADD	SYT6	ENSPPYP00000003795	ENSPPYP00000001170	MADD isoform 6.	SYT6 isoform 1.	0.766
PGLYRP3	PGLYRP4	ENSPPYP00000000955	ENSPPYP00000000954	Peptidoglycan recognition protein 3.	Peptidoglycan recognition protein 4.	0.831
PGLYRP3	SYT6	ENSPPYP00000000955	ENSPPYP00000001170	Peptidoglycan recognition protein 3.	SYT6 isoform 1.	0.533
PGLYRP4	PGLYRP3	ENSPPYP00000000954	ENSPPYP00000000955	Peptidoglycan recognition protein 4.	Peptidoglycan recognition protein 3.	0.831
PGLYRP4	SYT6	ENSPPYP00000000954	ENSPPYP00000001170	Peptidoglycan recognition protein 4.	SYT6 isoform 1.	0.716
PGLYRP4	ZP4	ENSPPYP00000000954	ENSPPYP00000000077	Peptidoglycan recognition protein 4.	ZP4 isoform 1.	0.424
STON2	DRD2	ENSPPYP00000006872	ENSPPYP00000004451	STON2 isoform 2; Belongs to the Stoned B family.	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.447
STON2	SYT10	ENSPPYP00000006872	ENSPPYP00000005031	STON2 isoform 2; Belongs to the Stoned B family.	Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity); Belongs to the synaptotagmin family.	0.548
STON2	SYT3	ENSPPYP00000006872	ENSPPYP00000011519	STON2 isoform 2; Belongs to the Stoned B family.	Synaptotagmin 3.	0.602
STON2	SYT6	ENSPPYP00000006872	ENSPPYP00000001170	STON2 isoform 2; Belongs to the Stoned B family.	SYT6 isoform 1.	0.596
STON2	SYT9	ENSPPYP00000006872	ENSPPYP00000024570	STON2 isoform 2; Belongs to the Stoned B family.	SYT9 isoform 2.	0.655
SYT10	DRD2	ENSPPYP00000005031	ENSPPYP00000004451	Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity); Belongs to the synaptotagmin family.	DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family.	0.431