STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN22Protein tyrosine phosphatase non-receptor type 22. (807 aa)    
Predicted Functional Partners:
CSK
Tyrosine-protein kinase.
   
 0.996
PSTPIP1
PSTPIP1 isoform 5.
   
 
 0.922
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
 
 0.755
JAK1
Tyrosine-protein kinase.
   
 0.746
ZAP70
Tyrosine-protein kinase.
   
 0.744
STAT4
Signal transducer and activator of transcription.
   
 0.740
LCK
Tyrosine-protein kinase.
   
 0.738
C1QBP
Complement C1q binding protein.
   
  
 0.718
CR201_G0049459
CD8A isoform 1.
   
 
 0.715
SHC1
SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).
   
 0.698
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (32%) [HD]