LRIG2 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

LRIG2

LRIG2 isoform 3. (888 aa)

Predicted Functional Partners:

LRIG1

0.795

GAL3ST1

0.674

MST1R

0.656

MET

0.656

TDRD3

0.624

HPSE2

0.616

ZNF490

0.598

OSBPL3

0.586

BIRC6

0.568

ANKLE2

0.546

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKLE2	LRIG2	ENSPPYP00000005864	ENSPPYP00000001181	ANKLE2 isoform 1.	LRIG2 isoform 3.	0.546
BIRC6	LRIG2	ENSPPYP00000013966	ENSPPYP00000001181	BIRC6 isoform 1.	LRIG2 isoform 3.	0.568
GAL3ST1	LRIG1	ENSPPYP00000013068	ENSPPYP00000015363	GAL3ST1 isoform 1.	LRIG1 isoform 3.	0.743
GAL3ST1	LRIG2	ENSPPYP00000013068	ENSPPYP00000001181	GAL3ST1 isoform 1.	LRIG2 isoform 3.	0.674
HPSE2	LRIG2	ENSPPYP00000002960	ENSPPYP00000001181	HPSE2 isoform 2.	LRIG2 isoform 3.	0.616
LRIG1	GAL3ST1	ENSPPYP00000015363	ENSPPYP00000013068	LRIG1 isoform 3.	GAL3ST1 isoform 1.	0.743
LRIG1	LRIG2	ENSPPYP00000015363	ENSPPYP00000001181	LRIG1 isoform 3.	LRIG2 isoform 3.	0.795
LRIG1	MET	ENSPPYP00000015363	ENSPPYP00000020106	LRIG1 isoform 3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.966
LRIG1	MST1R	ENSPPYP00000015363	ENSPPYP00000015506	LRIG1 isoform 3.	MST1R isoform 1.	0.796
LRIG2	ANKLE2	ENSPPYP00000001181	ENSPPYP00000005864	LRIG2 isoform 3.	ANKLE2 isoform 1.	0.546
LRIG2	BIRC6	ENSPPYP00000001181	ENSPPYP00000013966	LRIG2 isoform 3.	BIRC6 isoform 1.	0.568
LRIG2	GAL3ST1	ENSPPYP00000001181	ENSPPYP00000013068	LRIG2 isoform 3.	GAL3ST1 isoform 1.	0.674
LRIG2	HPSE2	ENSPPYP00000001181	ENSPPYP00000002960	LRIG2 isoform 3.	HPSE2 isoform 2.	0.616
LRIG2	LRIG1	ENSPPYP00000001181	ENSPPYP00000015363	LRIG2 isoform 3.	LRIG1 isoform 3.	0.795
LRIG2	MET	ENSPPYP00000001181	ENSPPYP00000020106	LRIG2 isoform 3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.656
LRIG2	MST1R	ENSPPYP00000001181	ENSPPYP00000015506	LRIG2 isoform 3.	MST1R isoform 1.	0.656
LRIG2	OSBPL3	ENSPPYP00000001181	ENSPPYP00000019863	LRIG2 isoform 3.	Oxysterol-binding protein; Belongs to the OSBP family.	0.586
LRIG2	TDRD3	ENSPPYP00000001181	ENSPPYP00000006153	LRIG2 isoform 3.	TDRD3 isoform 1.	0.624
LRIG2	ZNF490	ENSPPYP00000001181	ENSPPYP00000023792	LRIG2 isoform 3.	KRAB domain-containing zinc finger protein.	0.598
MET	LRIG1	ENSPPYP00000020106	ENSPPYP00000015363	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	LRIG1 isoform 3.	0.966