STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WNT2BWingless-type mmtv integration site family, member 2; Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors (391 aa)    
Predicted Functional Partners:
LRP6
annotation not available
   
 0.927
FZD7
Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family
   
 0.925
FZD9
Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family
   
 0.912
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family
   
 0.901
FZD2
Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family
   
 0.895
FZD1
Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family
   
 0.895
PORCN
Protein-serine o-palmitoleoyltransferase porcupine isoform x4; Porcupine homolog (Drosophila); Belongs to the membrane-bound acyltransferase family
    
 0.892
FZD10
Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family
   
 0.887
WIF1
WNT inhibitory factor 1
   
 0.885
FZD6
Frizzled-6 precursor; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways [...]
    
 0.878
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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