WNT2B protein (Pongo abelii) - STRING interaction network

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WNT2B

Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)

Predicted Functional Partners:

LRP6

0.966

PORCN

0.956

WIF1

0.954

CR201_G0021182

0.937

FZD3

0.933

GPC3

0.930

CER1

0.904

FZD6

0.872

FZD5

0.867

FZD7

0.859

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CER1	WNT2B	ENSPPYP00000021520	ENSPPYP00000001192	CER1 isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.904
CR201_G0021182	GPC3	ENSPPYP00000009831	ENSPPYP00000023206	NOTUM isoform 1.	GPC3 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.724
CR201_G0021182	WIF1	ENSPPYP00000009831	ENSPPYP00000005391	NOTUM isoform 1.	WIF1 isoform 1.	0.406
CR201_G0021182	WNT2B	ENSPPYP00000009831	ENSPPYP00000001192	NOTUM isoform 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.937
FZD3	FZD5	ENSPPYP00000020708	ENSPPYP00000014662	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.479
FZD3	FZD6	ENSPPYP00000020708	ENSPPYP00000021096	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	0.459
FZD3	LRP6	ENSPPYP00000020708	ENSPPYP00000024153	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.955
FZD3	WNT2B	ENSPPYP00000020708	ENSPPYP00000001192	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.933
FZD5	FZD3	ENSPPYP00000014662	ENSPPYP00000020708	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.479
FZD5	FZD6	ENSPPYP00000014662	ENSPPYP00000021096	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	0.507
FZD5	FZD7	ENSPPYP00000014662	ENSPPYP00000014616	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	0.940
FZD5	GPC3	ENSPPYP00000014662	ENSPPYP00000023206	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	GPC3 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.536
FZD5	LRP6	ENSPPYP00000014662	ENSPPYP00000024153	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.999
FZD5	WNT2B	ENSPPYP00000014662	ENSPPYP00000001192	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.867
FZD6	FZD3	ENSPPYP00000021096	ENSPPYP00000020708	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.459
FZD6	FZD5	ENSPPYP00000021096	ENSPPYP00000014662	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.507
FZD6	LRP6	ENSPPYP00000021096	ENSPPYP00000024153	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.972
FZD6	WNT2B	ENSPPYP00000021096	ENSPPYP00000001192	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.872
FZD7	FZD5	ENSPPYP00000014616	ENSPPYP00000014662	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.940
FZD7	LRP6	ENSPPYP00000014616	ENSPPYP00000024153	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.996

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