node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FZD1 | FZD2 | ENSPPYP00000019980 | ENSPPYP00000009362 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | 0.691 |
FZD1 | FZD4 | ENSPPYP00000019980 | ENSPPYP00000004289 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family | 0.511 |
FZD1 | FZD6 | ENSPPYP00000019980 | ENSPPYP00000021096 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled-6 precursor; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways [...] | 0.547 |
FZD1 | FZD7 | ENSPPYP00000019980 | ENSPPYP00000014616 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family | 0.525 |
FZD1 | LRP6 | ENSPPYP00000019980 | ENSPPYP00000024153 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | annotation not available | 0.979 |
FZD1 | WIF1 | ENSPPYP00000019980 | ENSPPYP00000005391 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | WNT inhibitory factor 1 | 0.765 |
FZD1 | WNT2B | ENSPPYP00000019980 | ENSPPYP00000001192 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | Wingless-type mmtv integration site family, member 2; Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors | 0.895 |
FZD10 | FZD6 | ENSPPYP00000005835 | ENSPPYP00000021096 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled-6 precursor; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways [...] | 0.503 |
FZD10 | LRP6 | ENSPPYP00000005835 | ENSPPYP00000024153 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family | annotation not available | 0.925 |
FZD10 | WIF1 | ENSPPYP00000005835 | ENSPPYP00000005391 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family | WNT inhibitory factor 1 | 0.636 |
FZD10 | WNT2B | ENSPPYP00000005835 | ENSPPYP00000001192 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family | Wingless-type mmtv integration site family, member 2; Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors | 0.887 |
FZD2 | FZD1 | ENSPPYP00000009362 | ENSPPYP00000019980 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | 0.691 |
FZD2 | FZD4 | ENSPPYP00000009362 | ENSPPYP00000004289 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family | 0.657 |
FZD2 | FZD6 | ENSPPYP00000009362 | ENSPPYP00000021096 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled-6 precursor; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways [...] | 0.647 |
FZD2 | LRP6 | ENSPPYP00000009362 | ENSPPYP00000024153 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | annotation not available | 0.970 |
FZD2 | WIF1 | ENSPPYP00000009362 | ENSPPYP00000005391 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | WNT inhibitory factor 1 | 0.726 |
FZD2 | WNT2B | ENSPPYP00000009362 | ENSPPYP00000001192 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | Wingless-type mmtv integration site family, member 2; Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors | 0.895 |
FZD4 | FZD1 | ENSPPYP00000004289 | ENSPPYP00000019980 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family | 0.511 |
FZD4 | FZD2 | ENSPPYP00000004289 | ENSPPYP00000009362 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family | 0.657 |
FZD4 | FZD6 | ENSPPYP00000004289 | ENSPPYP00000021096 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family | Frizzled-6 precursor; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways [...] | 0.712 |