Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LRIF1LRIF1 isoform 1. (742 aa)    
Predicted Functional Partners:
CBX3
Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...]
    
 
 0.801
CBX5
CBX5 isoform 2.
    
 
 0.786
SMCHD1
SMCHD1 isoform 1.
    
 
 0.731
ANKRD40
Ankyrin repeat domain 40.
      
 0.634
PRR14
PRR14 isoform 6.
    
 
 0.583
CNOT10
CNOT10 isoform 1.
      
 0.581
RANBP10
RAN binding protein 10.
      
 0.534
RMND5A
Required for meiotic nuclear division 5 homolog A.
      
 0.530
NIPBL
Nipped-B protein.
    
 
 0.528
SRBD1
S1 RNA-binding domain-containing protein 1.
      
 0.526
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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