| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCY1 | ADCY8 | ENSPPYP00000019703 | ENSPPYP00000021189 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.949 |
| ADCY1 | GNAI1 | ENSPPYP00000019703 | ENSPPYP00000020020 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(i) subunit alpha-1. | 0.947 |
| ADCY1 | GNAI2 | ENSPPYP00000019703 | ENSPPYP00000015499 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | GNAI2 isoform 1. | 0.941 |
| ADCY1 | GNAI3 | ENSPPYP00000019703 | ENSPPYP00000001241 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.959 |
| ADCY1 | GNB1 | ENSPPYP00000019703 | ENSPPYP00000002307 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.882 |
| ADCY8 | ADCY1 | ENSPPYP00000021189 | ENSPPYP00000019703 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.949 |
| ADCY8 | GNAI1 | ENSPPYP00000021189 | ENSPPYP00000020020 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(i) subunit alpha-1. | 0.946 |
| ADCY8 | GNAI2 | ENSPPYP00000021189 | ENSPPYP00000015499 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | GNAI2 isoform 1. | 0.942 |
| ADCY8 | GNAI3 | ENSPPYP00000021189 | ENSPPYP00000001241 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.964 |
| ADCY8 | GNB1 | ENSPPYP00000021189 | ENSPPYP00000002307 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.804 |
| DRD2 | GNAI1 | ENSPPYP00000004451 | ENSPPYP00000020020 | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein G(i) subunit alpha-1. | 0.990 |
| DRD2 | GNAI2 | ENSPPYP00000004451 | ENSPPYP00000015499 | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. | GNAI2 isoform 1. | 0.970 |
| DRD2 | GNAI3 | ENSPPYP00000004451 | ENSPPYP00000001241 | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.962 |
| DRD2 | GNB1 | ENSPPYP00000004451 | ENSPPYP00000002307 | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.989 |
| DRD2 | GPSM1 | ENSPPYP00000004451 | ENSPPYP00000022167 | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. | GPSM1 isoform 3. | 0.412 |
| DRD2 | SSTR2 | ENSPPYP00000004451 | ENSPPYP00000009640 | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. | Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.707 |
| GNAI1 | ADCY1 | ENSPPYP00000020020 | ENSPPYP00000019703 | Guanine nucleotide-binding protein G(i) subunit alpha-1. | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.947 |
| GNAI1 | ADCY8 | ENSPPYP00000020020 | ENSPPYP00000021189 | Guanine nucleotide-binding protein G(i) subunit alpha-1. | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.946 |
| GNAI1 | DRD2 | ENSPPYP00000020020 | ENSPPYP00000004451 | Guanine nucleotide-binding protein G(i) subunit alpha-1. | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. | 0.990 |
| GNAI1 | GNAI2 | ENSPPYP00000020020 | ENSPPYP00000015499 | Guanine nucleotide-binding protein G(i) subunit alpha-1. | GNAI2 isoform 1. | 0.955 |