Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SORT1Sortilin. (789 aa)    
Predicted Functional Partners:
NGFR
NGFR isoform 1.
    
 0.990
NTS
NTS isoform 1.
   
 
 0.958
APOB
APOB isoform 1.
     
 0.927
GRN
GRN isoform 1.
    
 
 0.924
LRPAP1
LRPAP1 isoform 1.
    
 
 0.922
GGA1
GGA1 isoform 1.
    
 
 0.919
BDNF
Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
    
 
 0.893
NGF
NGF isoform 1; Belongs to the NGF-beta family.
    
 
 0.891
SORCS1
SORCS1 isoform 1.
    
 
 0.864
CR201_G0034261
GGA2 isoform 1.
    
 
 0.839
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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