Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GPSM2GPSM2 isoform 1. (684 aa)    
Predicted Functional Partners:
GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]
   
 0.889
HSPB6
HSPB6 isoform 1; Belongs to the small heat shock protein (HSP20) family.
      
 0.888
TBC1D21
TBC1 domain family member 21.
      
 0.882
FN3K
FN3K isoform 1; Belongs to the fructosamine kinase family.
      
 0.882
ENSPPYP00000002678
annotation not available
   
 0.860
GNAI2
GNAI2 isoform 1.
   
 0.860
CIZ1
CIZ1 isoform 13.
    
 
 0.855
FRMPD4
FRMPD4 isoform 1.
    
 
 0.824
FRMPD1
FRMPD1 isoform 1.
    
 
 0.812
GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1.
   
 0.808
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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