Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VAV3VAV3 isoform 1. (824 aa)    
Predicted Functional Partners:
LCP2
LCP2 isoform 3.
   
 0.991
SYK
Tyrosine-protein kinase.
   
 0.990
VAV1
VAV1 isoform 2.
  
 
 
0.985
CD19
CD19 isoform 3.
   
 0.982
CDC42
Cell division cycle 42.
   
 0.973
ZAP70
Tyrosine-protein kinase.
   
 0.973
RAC2
Rac family small GTPase 2.
   
 0.966
RAC3
RAC3 isoform 1.
   
 0.964
RAC1
Rac family small GTPase 1.
   
 0.964
PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
   
0.958
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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