SASS6 protein (Pongo abelii) - STRING interaction network

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

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Score

SASS6

SAS-6 centriolar assembly protein. (657 aa)

Predicted Functional Partners:

FANCM

0.977

WRN

0.973

CEP135

0.923

STIL

0.918

CENPJ

0.906

PLK4

0.896

MEIOB

0.865

RPA3

0.816

PRIM1

0.784

PRIM2

0.781

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CENPJ	CEP135	ENSPPYP00000005941	ENSPPYP00000016481	CENPJ isoform 2.	CEP135 isoform 2.	0.860
CENPJ	PLK4	ENSPPYP00000005941	ENSPPYP00000016820	CENPJ isoform 2.	Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...]	0.933
CENPJ	SASS6	ENSPPYP00000005941	ENSPPYP00000001299	CENPJ isoform 2.	SAS-6 centriolar assembly protein.	0.906
CENPJ	STIL	ENSPPYP00000005941	ENSPPYP00000001600	CENPJ isoform 2.	STIL isoform 3.	0.954
CEP135	CENPJ	ENSPPYP00000016481	ENSPPYP00000005941	CEP135 isoform 2.	CENPJ isoform 2.	0.860
CEP135	PLK4	ENSPPYP00000016481	ENSPPYP00000016820	CEP135 isoform 2.	Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...]	0.881
CEP135	SASS6	ENSPPYP00000016481	ENSPPYP00000001299	CEP135 isoform 2.	SAS-6 centriolar assembly protein.	0.923
CEP135	STIL	ENSPPYP00000016481	ENSPPYP00000001600	CEP135 isoform 2.	STIL isoform 3.	0.756
FANCM	MEIOB	ENSPPYP00000006571	ENSPPYP00000007889	FANCM isoform 2.	MEIOB isoform 4.	0.993
FANCM	PLK4	ENSPPYP00000006571	ENSPPYP00000016820	FANCM isoform 2.	Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...]	0.494
FANCM	RPA3	ENSPPYP00000006571	ENSPPYP00000019939	FANCM isoform 2.	Replication protein A3.	0.919
FANCM	SASS6	ENSPPYP00000006571	ENSPPYP00000001299	FANCM isoform 2.	SAS-6 centriolar assembly protein.	0.977
FANCM	WRN	ENSPPYP00000006571	ENSPPYP00000020730	FANCM isoform 2.	WRN isoform 1.	0.983
MEIOB	FANCM	ENSPPYP00000007889	ENSPPYP00000006571	MEIOB isoform 4.	FANCM isoform 2.	0.993
MEIOB	PRIM1	ENSPPYP00000007889	ENSPPYP00000005323	MEIOB isoform 4.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.763
MEIOB	PRIM2	ENSPPYP00000007889	ENSPPYP00000018731	MEIOB isoform 4.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.767
MEIOB	RPA3	ENSPPYP00000007889	ENSPPYP00000019939	MEIOB isoform 4.	Replication protein A3.	0.952
MEIOB	SASS6	ENSPPYP00000007889	ENSPPYP00000001299	MEIOB isoform 4.	SAS-6 centriolar assembly protein.	0.865
MEIOB	WRN	ENSPPYP00000007889	ENSPPYP00000020730	MEIOB isoform 4.	WRN isoform 1.	0.992
PLK4	CENPJ	ENSPPYP00000016820	ENSPPYP00000005941	Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...]	CENPJ isoform 2.	0.933