Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FRRS1FRRS1 isoform 3. (618 aa)    
Predicted Functional Partners:
CYB561
Cytochrome b561; Secretory vesicle-specific electron transport protein.
      
 0.729
RPTOR
RPTOR isoform 4.
    
 0.618
PDPK1
PDPK1 isoform 1.
    
 0.614
MAPKAP1
Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...]
    
 0.611
RICTOR
RICTOR isoform 1.
    
 0.607
MLST8
MTOR associated protein, LST8 homolog.
    
 0.567
TSC2
TSC2 isoform 1.
    
 0.562
RPS6
40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 0.548
ENSPPYP00000021673
annotation not available
    
 0.548
SMG1
SMG1 isoform 8; Belongs to the PI3/PI4-kinase family.
    
 0.539
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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