TMED5 protein (Pongo abelii) - STRING interaction network

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TMED5

Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity). (278 aa)

Predicted Functional Partners:

TMED10

0.956

TMED2

0.934

TM9SF4

0.883

TMED9

0.863

EEF1AKNMT

0.846

TMED4

0.829

LIPG

0.736

GNL3L

0.695

PLAGL2

0.682

HCK

0.658

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF1AKNMT	HCK	ENSPPYP00000000590	ENSPPYP00000012176	METTL13 isoform 4.	Tyrosine-protein kinase.	0.508
EEF1AKNMT	PLAGL2	ENSPPYP00000000590	ENSPPYP00000012179	METTL13 isoform 4.	PLAGL2 isoform 1.	0.540
EEF1AKNMT	TM9SF4	ENSPPYP00000000590	ENSPPYP00000012177	METTL13 isoform 4.	Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	0.822
EEF1AKNMT	TMED5	ENSPPYP00000000590	ENSPPYP00000001331	METTL13 isoform 4.	Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).	0.846
GNL3L	TMED5	ENSPPYP00000022817	ENSPPYP00000001331	GNL3L isoform 1.	Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).	0.695
HCK	EEF1AKNMT	ENSPPYP00000012176	ENSPPYP00000000590	Tyrosine-protein kinase.	METTL13 isoform 4.	0.508
HCK	PLAGL2	ENSPPYP00000012176	ENSPPYP00000012179	Tyrosine-protein kinase.	PLAGL2 isoform 1.	0.676
HCK	TM9SF4	ENSPPYP00000012176	ENSPPYP00000012177	Tyrosine-protein kinase.	Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	0.829
HCK	TMED5	ENSPPYP00000012176	ENSPPYP00000001331	Tyrosine-protein kinase.	Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).	0.658
LIPG	TMED10	ENSPPYP00000010283	ENSPPYP00000024352	Lipase G, endothelial type.	Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...]	0.521
LIPG	TMED4	ENSPPYP00000010283	ENSPPYP00000019713	Lipase G, endothelial type.	Transmembrane p24 trafficking protein 4.	0.465
LIPG	TMED5	ENSPPYP00000010283	ENSPPYP00000001331	Lipase G, endothelial type.	Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).	0.736
PLAGL2	EEF1AKNMT	ENSPPYP00000012179	ENSPPYP00000000590	PLAGL2 isoform 1.	METTL13 isoform 4.	0.540
PLAGL2	HCK	ENSPPYP00000012179	ENSPPYP00000012176	PLAGL2 isoform 1.	Tyrosine-protein kinase.	0.676
PLAGL2	TM9SF4	ENSPPYP00000012179	ENSPPYP00000012177	PLAGL2 isoform 1.	Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	0.858
PLAGL2	TMED5	ENSPPYP00000012179	ENSPPYP00000001331	PLAGL2 isoform 1.	Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity).	0.682
TM9SF4	EEF1AKNMT	ENSPPYP00000012177	ENSPPYP00000000590	Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	METTL13 isoform 4.	0.822
TM9SF4	HCK	ENSPPYP00000012177	ENSPPYP00000012176	Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	Tyrosine-protein kinase.	0.829
TM9SF4	PLAGL2	ENSPPYP00000012177	ENSPPYP00000012179	Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	PLAGL2 isoform 1.	0.858
TM9SF4	TMED10	ENSPPYP00000012177	ENSPPYP00000024352	Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.	Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...]	0.477

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