| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1A1 | EPHX1 | ENSPPYP00000001636 | ENSPPYP00000000173 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.910 |
| AKR1A1 | EPHX3 | ENSPPYP00000001636 | ENSPPYP00000010836 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | EPHX3 isoform 1. | 0.903 |
| AKR1A1 | EPHX4 | ENSPPYP00000001636 | ENSPPYP00000001342 | Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hypergly [...] | Epoxide hydrolase 4. | 0.903 |
| AKR1C2 | AKR1C4 | ENSPPYP00000002373 | ENSPPYP00000002376 | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | 0.870 |
| AKR1C2 | AKR1C8P | ENSPPYP00000002373 | ENSPPYP00000002377 | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | Prostaglandin F synthase 1-like isoform X1. | 0.901 |
| AKR1C2 | CYP1A1 | ENSPPYP00000002373 | ENSPPYP00000007536 | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | CYP1A1 isoform 1; Belongs to the cytochrome P450 family. | 0.909 |
| AKR1C2 | EPHX1 | ENSPPYP00000002373 | ENSPPYP00000000173 | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.910 |
| AKR1C2 | EPHX3 | ENSPPYP00000002373 | ENSPPYP00000010836 | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | EPHX3 isoform 1. | 0.904 |
| AKR1C2 | EPHX4 | ENSPPYP00000002373 | ENSPPYP00000001342 | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | Epoxide hydrolase 4. | 0.903 |
| AKR1C4 | AKR1C2 | ENSPPYP00000002376 | ENSPPYP00000002373 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | 0.870 |
| AKR1C4 | AKR1C8P | ENSPPYP00000002376 | ENSPPYP00000002377 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | Prostaglandin F synthase 1-like isoform X1. | 0.901 |
| AKR1C4 | EPHX1 | ENSPPYP00000002376 | ENSPPYP00000000173 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.907 |
| AKR1C4 | EPHX3 | ENSPPYP00000002376 | ENSPPYP00000010836 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | EPHX3 isoform 1. | 0.904 |
| AKR1C4 | EPHX4 | ENSPPYP00000002376 | ENSPPYP00000001342 | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | Epoxide hydrolase 4. | 0.903 |
| AKR1C8P | AKR1C2 | ENSPPYP00000002377 | ENSPPYP00000002373 | Prostaglandin F synthase 1-like isoform X1. | Aldo-keto reductase family 1 member C1 homolog; Belongs to the aldo/keto reductase family. | 0.901 |
| AKR1C8P | AKR1C4 | ENSPPYP00000002377 | ENSPPYP00000002376 | Prostaglandin F synthase 1-like isoform X1. | Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | 0.901 |
| AKR1C8P | CYP1A1 | ENSPPYP00000002377 | ENSPPYP00000007536 | Prostaglandin F synthase 1-like isoform X1. | CYP1A1 isoform 1; Belongs to the cytochrome P450 family. | 0.904 |
| AKR1C8P | EPHX1 | ENSPPYP00000002377 | ENSPPYP00000000173 | Prostaglandin F synthase 1-like isoform X1. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.906 |
| AKR1C8P | EPHX3 | ENSPPYP00000002377 | ENSPPYP00000010836 | Prostaglandin F synthase 1-like isoform X1. | EPHX3 isoform 1. | 0.904 |
| AKR1C8P | EPHX4 | ENSPPYP00000002377 | ENSPPYP00000001342 | Prostaglandin F synthase 1-like isoform X1. | Epoxide hydrolase 4. | 0.903 |
