HFM1 protein (Pongo abelii) - STRING interaction network

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second shell of interactors

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

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Score

HFM1

HFM1 isoform 1. (1434 aa)

Predicted Functional Partners:

PRPF8

0.919

PRPF6

0.880

ASCC2

0.836

SNRPF

0.833

SNRPD3

0.831

SART1

0.775

SNRNP40

0.774

SF3B3

0.766

PRPF31

0.761

SNW1

0.751

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCC2	HFM1	ENSPPYP00000013050	ENSPPYP00000001347	ASCC2 isoform 1.	HFM1 isoform 1.	0.836
HFM1	ASCC2	ENSPPYP00000001347	ENSPPYP00000013050	HFM1 isoform 1.	ASCC2 isoform 1.	0.836
HFM1	PRPF31	ENSPPYP00000001347	ENSPPYP00000024738	HFM1 isoform 1.	Pre-mRNA processing factor 31.	0.761
HFM1	PRPF6	ENSPPYP00000001347	ENSPPYP00000012574	HFM1 isoform 1.	Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.	0.880
HFM1	PRPF8	ENSPPYP00000001347	ENSPPYP00000008763	HFM1 isoform 1.	Pre-mRNA processing factor 8.	0.919
HFM1	SART1	ENSPPYP00000001347	ENSPPYP00000003517	HFM1 isoform 1.	SART1 isoform 1.	0.775
HFM1	SF3B3	ENSPPYP00000001347	ENSPPYP00000008511	HFM1 isoform 1.	Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...]	0.766
HFM1	SNRNP40	ENSPPYP00000001347	ENSPPYP00000001868	HFM1 isoform 1.	U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome.	0.774
HFM1	SNRPD3	ENSPPYP00000001347	ENSPPYP00000012995	HFM1 isoform 1.	Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.	0.831
HFM1	SNRPF	ENSPPYP00000001347	ENSPPYP00000005530	HFM1 isoform 1.	Small nuclear ribonucleoprotein polypeptide F.	0.833
HFM1	SNW1	ENSPPYP00000001347	ENSPPYP00000006859	HFM1 isoform 1.	SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...]	0.751
PRPF31	HFM1	ENSPPYP00000024738	ENSPPYP00000001347	Pre-mRNA processing factor 31.	HFM1 isoform 1.	0.761
PRPF31	PRPF6	ENSPPYP00000024738	ENSPPYP00000012574	Pre-mRNA processing factor 31.	Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.	0.999
PRPF31	PRPF8	ENSPPYP00000024738	ENSPPYP00000008763	Pre-mRNA processing factor 31.	Pre-mRNA processing factor 8.	0.993
PRPF31	SART1	ENSPPYP00000024738	ENSPPYP00000003517	Pre-mRNA processing factor 31.	SART1 isoform 1.	0.978
PRPF31	SF3B3	ENSPPYP00000024738	ENSPPYP00000008511	Pre-mRNA processing factor 31.	Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...]	0.946
PRPF31	SNRNP40	ENSPPYP00000024738	ENSPPYP00000001868	Pre-mRNA processing factor 31.	U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome.	0.942
PRPF31	SNRPD3	ENSPPYP00000024738	ENSPPYP00000012995	Pre-mRNA processing factor 31.	Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.	0.952
PRPF31	SNRPF	ENSPPYP00000024738	ENSPPYP00000005530	Pre-mRNA processing factor 31.	Small nuclear ribonucleoprotein polypeptide F.	0.942
PRPF6	HFM1	ENSPPYP00000012574	ENSPPYP00000001347	Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.	HFM1 isoform 1.	0.880