GBP4 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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co-expression

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gene neighborhood

gene co-occurrence

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[Homology]

Score

GBP4

GBP4 isoform 1. (640 aa)

Predicted Functional Partners:

GBP5

0.887

STAT1

0.551

GBP2

0.475

GBP1

0.475

GBP3

0.475

EPSTI1

0.453

SFN

0.451

CXCL10

0.446

IRF1

0.446

FURIN

0.438

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCL10	GBP1	ENSPPYP00000016587	ENSPPYP00000001360	C-X-C motif chemokine.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	0.597
CXCL10	GBP4	ENSPPYP00000016587	ENSPPYP00000001357	C-X-C motif chemokine.	GBP4 isoform 1.	0.446
CXCL10	GBP5	ENSPPYP00000016587	ENSPPYP00000023860	C-X-C motif chemokine.	GBP5 isoform 2.	0.441
CXCL10	IRF1	ENSPPYP00000016587	ENSPPYP00000017628	C-X-C motif chemokine.	Interferon regulatory factor.	0.632
CXCL10	STAT1	ENSPPYP00000016587	ENSPPYP00000014555	C-X-C motif chemokine.	Signal transducer and activator of transcription.	0.799
EPSTI1	GBP1	ENSPPYP00000006062	ENSPPYP00000001360	EPSTI1 isoform 2.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	0.480
EPSTI1	GBP4	ENSPPYP00000006062	ENSPPYP00000001357	EPSTI1 isoform 2.	GBP4 isoform 1.	0.453
EPSTI1	STAT1	ENSPPYP00000006062	ENSPPYP00000014555	EPSTI1 isoform 2.	Signal transducer and activator of transcription.	0.618
FURIN	GBP1	ENSPPYP00000007695	ENSPPYP00000001360	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	0.598
FURIN	GBP2	ENSPPYP00000007695	ENSPPYP00000001358	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Guanylate binding protein 2.	0.796
FURIN	GBP3	ENSPPYP00000007695	ENSPPYP00000001361	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	GBP3 isoform 2.	0.598
FURIN	GBP4	ENSPPYP00000007695	ENSPPYP00000001357	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	GBP4 isoform 1.	0.438
FURIN	GBP5	ENSPPYP00000007695	ENSPPYP00000023860	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	GBP5 isoform 2.	0.875
GBP1	CXCL10	ENSPPYP00000001360	ENSPPYP00000016587	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	C-X-C motif chemokine.	0.597
GBP1	EPSTI1	ENSPPYP00000001360	ENSPPYP00000006062	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	EPSTI1 isoform 2.	0.480
GBP1	FURIN	ENSPPYP00000001360	ENSPPYP00000007695	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.598
GBP1	GBP2	ENSPPYP00000001360	ENSPPYP00000001358	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	Guanylate binding protein 2.	0.964
GBP1	GBP3	ENSPPYP00000001360	ENSPPYP00000001361	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	GBP3 isoform 2.	0.991
GBP1	GBP4	ENSPPYP00000001360	ENSPPYP00000001357	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	GBP4 isoform 1.	0.475
GBP1	GBP5	ENSPPYP00000001360	ENSPPYP00000023860	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	GBP5 isoform 2.	0.924