GBP1 protein (Pongo abelii) - STRING interaction network

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GBP1

Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). (590 aa)

Predicted Functional Partners:

GBP3

0.991

GBP2

0.964

GBP5

0.924

STAT1

0.844

SFN

0.818

IFIT3

0.626

IRF1

0.607

FURIN

0.598

CASP1

0.597

CXCL10

0.597

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	GBP1	ENSPPYP00000004375	ENSPPYP00000001360	CASP1 isoform 4; Belongs to the peptidase C14A family.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	0.597
CASP1	GBP2	ENSPPYP00000004375	ENSPPYP00000001358	CASP1 isoform 4; Belongs to the peptidase C14A family.	Guanylate binding protein 2.	0.471
CASP1	GBP3	ENSPPYP00000004375	ENSPPYP00000001361	CASP1 isoform 4; Belongs to the peptidase C14A family.	GBP3 isoform 2.	0.431
CASP1	GBP5	ENSPPYP00000004375	ENSPPYP00000023860	CASP1 isoform 4; Belongs to the peptidase C14A family.	GBP5 isoform 2.	0.440
CASP1	IRF1	ENSPPYP00000004375	ENSPPYP00000017628	CASP1 isoform 4; Belongs to the peptidase C14A family.	Interferon regulatory factor.	0.482
CASP1	STAT1	ENSPPYP00000004375	ENSPPYP00000014555	CASP1 isoform 4; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.403
CXCL10	GBP1	ENSPPYP00000016587	ENSPPYP00000001360	C-X-C motif chemokine.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	0.597
CXCL10	GBP5	ENSPPYP00000016587	ENSPPYP00000023860	C-X-C motif chemokine.	GBP5 isoform 2.	0.441
CXCL10	IFIT3	ENSPPYP00000016587	ENSPPYP00000002854	C-X-C motif chemokine.	Interferon induced protein with tetratricopeptide repeats 3.	0.564
CXCL10	IRF1	ENSPPYP00000016587	ENSPPYP00000017628	C-X-C motif chemokine.	Interferon regulatory factor.	0.632
CXCL10	STAT1	ENSPPYP00000016587	ENSPPYP00000014555	C-X-C motif chemokine.	Signal transducer and activator of transcription.	0.799
FURIN	GBP1	ENSPPYP00000007695	ENSPPYP00000001360	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	0.598
FURIN	GBP2	ENSPPYP00000007695	ENSPPYP00000001358	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Guanylate binding protein 2.	0.796
FURIN	GBP3	ENSPPYP00000007695	ENSPPYP00000001361	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	GBP3 isoform 2.	0.598
FURIN	GBP5	ENSPPYP00000007695	ENSPPYP00000023860	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	GBP5 isoform 2.	0.875
GBP1	CASP1	ENSPPYP00000001360	ENSPPYP00000004375	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	CASP1 isoform 4; Belongs to the peptidase C14A family.	0.597
GBP1	CXCL10	ENSPPYP00000001360	ENSPPYP00000016587	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	C-X-C motif chemokine.	0.597
GBP1	FURIN	ENSPPYP00000001360	ENSPPYP00000007695	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.598
GBP1	GBP2	ENSPPYP00000001360	ENSPPYP00000001358	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	Guanylate binding protein 2.	0.964
GBP1	GBP3	ENSPPYP00000001360	ENSPPYP00000001361	Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).	GBP3 isoform 2.	0.991

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