HS2ST1 protein (Pongo abelii) - STRING interaction network

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HS2ST1

Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family. (359 aa)

Predicted Functional Partners:

SDC1

0.652

HS6ST1

0.643

DIAPH3

0.634

GLCE

0.618

FBXW2

0.613

CR201_G0049379

0.611

NDST1

0.597

GPC6

0.581

GPC2

0.581

AKAP13

0.573

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP13	FBXW2	ENSPPYP00000007653	ENSPPYP00000021912	AKAP13 isoform 5.	FBXW2 isoform 1.	0.665
AKAP13	HS2ST1	ENSPPYP00000007653	ENSPPYP00000001370	AKAP13 isoform 5.	Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family.	0.573
CR201_G0049379	GLCE	ENSPPYP00000014918	ENSPPYP00000007480	GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Glucuronic acid epimerase.	0.463
CR201_G0049379	GPC6	ENSPPYP00000014918	ENSPPYP00000006200	GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Secreted glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity).	0.408
CR201_G0049379	HS2ST1	ENSPPYP00000014918	ENSPPYP00000001370	GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family.	0.611
CR201_G0049379	HS6ST1	ENSPPYP00000014918	ENSPPYP00000014230	GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	0.501
CR201_G0049379	NDST1	ENSPPYP00000014918	ENSPPYP00000017851	GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	N-deacetylase and N-sulfotransferase 1.	0.432
CR201_G0049379	SDC1	ENSPPYP00000014918	ENSPPYP00000014091	GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.982
DIAPH3	HS2ST1	ENSPPYP00000006152	ENSPPYP00000001370	DIAPH3 isoform 1.	Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family.	0.634
FBXW2	AKAP13	ENSPPYP00000021912	ENSPPYP00000007653	FBXW2 isoform 1.	AKAP13 isoform 5.	0.665
FBXW2	HS2ST1	ENSPPYP00000021912	ENSPPYP00000001370	FBXW2 isoform 1.	Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family.	0.613
GLCE	CR201_G0049379	ENSPPYP00000007480	ENSPPYP00000014918	Glucuronic acid epimerase.	GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.463
GLCE	GPC2	ENSPPYP00000007480	ENSPPYP00000019506	Glucuronic acid epimerase.	GPC2 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.463
GLCE	GPC6	ENSPPYP00000007480	ENSPPYP00000006200	Glucuronic acid epimerase.	Secreted glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity).	0.463
GLCE	HS2ST1	ENSPPYP00000007480	ENSPPYP00000001370	Glucuronic acid epimerase.	Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family.	0.618
GLCE	HS6ST1	ENSPPYP00000007480	ENSPPYP00000014230	Glucuronic acid epimerase.	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.	0.810
GLCE	NDST1	ENSPPYP00000007480	ENSPPYP00000017851	Glucuronic acid epimerase.	N-deacetylase and N-sulfotransferase 1.	0.956
GLCE	SDC1	ENSPPYP00000007480	ENSPPYP00000014091	Glucuronic acid epimerase.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.517
GPC2	GLCE	ENSPPYP00000019506	ENSPPYP00000007480	GPC2 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Glucuronic acid epimerase.	0.463
GPC2	HS2ST1	ENSPPYP00000019506	ENSPPYP00000001370	GPC2 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). Belongs to the sulfotransferase 3 family.	0.581

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