Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
BCL10BCL10 isoform 1. (263 aa)    
Predicted Functional Partners:
MALT1
MALT1 isoform 1.
    
 0.999
CARD9
CARD9 isoform 1.
    
 0.999
CARD11
CARD11 isoform 1.
    
 0.998
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.997
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 0.994
CHUK
CHUK isoform 1.
   
 0.993
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...]
   
 0.980
CASP8
CASP8 isoform 1; Belongs to the peptidase C14A family.
   
 0.933
MAPK9
Mitogen-activated protein kinase.
    
 0.915
MAPK8
Mitogen-activated protein kinase.
    
 0.910
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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