Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MCOLN3MCOLN3 isoform 4. (553 aa)    
Predicted Functional Partners:
MCOLN2
MCOLN2 isoform 1.
  
 
 
0.979
TFEB
TFEB isoform 3.
   
 
 0.634
ATP6V1H
V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
      
 0.588
TRPV6
TRPV6 isoform 1.
     
 0.516
CCDC112
CCDC112 isoform 1.
      
 0.510
TRPA1
TRPA1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.505
TRPM2
TRPM2 isoform 3.
     
 0.496
TRPC3
Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family.
   
 
 0.447
USH1C
USH1C isoform 9.
      
 0.446
TRPM1
TRPM1 isoform 2.
   
 
 0.446
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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