| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADCY5 | GIPR | ENSPPYP00000015070 | ENSPPYP00000011327 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | GIPR isoform 4; Belongs to the G-protein coupled receptor 2 family. | 0.592 |
| ADCY5 | GNAI3 | ENSPPYP00000015070 | ENSPPYP00000001241 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.959 |
| ADCY5 | GNAO1 | ENSPPYP00000015070 | ENSPPYP00000008317 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | GNAO1 isoform 1. | 0.954 |
| ADCY5 | GNAS | ENSPPYP00000015070 | ENSPPYP00000012485 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | GNAS isoform 2. | 0.986 |
| ADCY5 | GNG5 | ENSPPYP00000015070 | ENSPPYP00000001395 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.937 |
| CALCR | GNAI3 | ENSPPYP00000019965 | ENSPPYP00000001241 | CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.903 |
| CALCR | GNAO1 | ENSPPYP00000019965 | ENSPPYP00000008317 | CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family. | GNAO1 isoform 1. | 0.904 |
| CALCR | GNAS | ENSPPYP00000019965 | ENSPPYP00000012485 | CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family. | GNAS isoform 2. | 0.933 |
| CALCR | GNG5 | ENSPPYP00000019965 | ENSPPYP00000001395 | CALCR isoform 1; Belongs to the G-protein coupled receptor 2 family. | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.939 |
| CR201_G0049912 | GNAO1 | ENSPPYP00000023347 | ENSPPYP00000008317 | Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | GNAO1 isoform 1. | 0.537 |
| CR201_G0049912 | GNAS | ENSPPYP00000023347 | ENSPPYP00000012485 | Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | GNAS isoform 2. | 0.956 |
| CR201_G0049912 | GNG5 | ENSPPYP00000023347 | ENSPPYP00000001395 | Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.933 |
| GABBR2 | GNAI3 | ENSPPYP00000021779 | ENSPPYP00000001241 | GABBR2 isoform 2. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.937 |
| GABBR2 | GNAO1 | ENSPPYP00000021779 | ENSPPYP00000008317 | GABBR2 isoform 2. | GNAO1 isoform 1. | 0.937 |
| GABBR2 | GNG5 | ENSPPYP00000021779 | ENSPPYP00000001395 | GABBR2 isoform 2. | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.935 |
| GABBR2 | OPRM1 | ENSPPYP00000021779 | ENSPPYP00000024191 | GABBR2 isoform 2. | Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. | 0.404 |
| GIPR | ADCY5 | ENSPPYP00000011327 | ENSPPYP00000015070 | GIPR isoform 4; Belongs to the G-protein coupled receptor 2 family. | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. | 0.592 |
| GIPR | GNAS | ENSPPYP00000011327 | ENSPPYP00000012485 | GIPR isoform 4; Belongs to the G-protein coupled receptor 2 family. | GNAS isoform 2. | 0.942 |
| GIPR | GNG5 | ENSPPYP00000011327 | ENSPPYP00000001395 | GIPR isoform 4; Belongs to the G-protein coupled receptor 2 family. | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.932 |
| GLP1R | GNAI3 | ENSPPYP00000018535 | ENSPPYP00000001241 | Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] | 0.500 |
