Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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PRKACBPRKACB isoform 9; Belongs to the protein kinase superfamily. (354 aa)    
Predicted Functional Partners:
PRKAR1A
cAMP-dependent protein kinase type I-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
 
 
 0.999
PRKAR2B
PRKAR2B isoform 1.
   
 0.998
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
   
 0.997
PRKACG
Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.
  
0.997
ENSPPYP00000020490
annotation not available
   
 0.989
PPP1R1B
Protein phosphatase 1 regulatory inhibitor subunit 1B.
    
 0.988
CREB1
CREB1 isoform 1.
    
 0.985
AKAP1
AKAP1 isoform 10.
    
 0.984
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.984
PKIA
cAMP-dependent protein kinase inhibitor; Belongs to the PKI family.
   
 0.981
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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