Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
IFI44IFI44 isoform 2. (422 aa)    
Predicted Functional Partners:
RSAD2
Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...]
   
  
 0.972
ISG15
ISG15 ubiquitin like modifier.
   
 
 0.947
IFIH1
IFIH1 isoform 1.
   
 
 0.937
IFIT3
Interferon induced protein with tetratricopeptide repeats 3.
   
  
 0.934
IFIT2
IFIT2 isoform 1.
   
  
 0.926
OAS1
OAS1 isoform 2.
   
  
 0.924
IFI6
Interferon alpha inducible protein 6.
   
 
 0.919
OAS2
OAS2 isoform 1.
   
  
 0.918
MX1
Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity.
   
  
 0.917
IFIT1
Interferon induced protein with tetratricopeptide repeats 1.
   
  
 0.916
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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