Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LHX8LHX8 isoform 1. (356 aa)    
Predicted Functional Partners:
CRYZ
Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).
    
 
 0.862
FIGLA
FIGLA isoform 1.
   
 0.817
ENSPPYP00000014214
annotation not available
   
 0.817
LDB1
LIM domain binding 1.
    
 0.809
SOHLH1
SOHLH1 isoform 1.
    
 
 0.763
CR201_G0049573
NOBOX isoform 2.
      
 0.692
LDB2
LDB2 isoform 1.
    
 0.673
GBX1
GBX1 isoform 1.
   
 0.666
DLX2
Distal-less homeobox 2.
   
 
 0.621
KLF3
Kruppel like factor 3.
   
 0.573
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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