TYW3 protein (Pongo abelii) - STRING interaction network

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TYW3

tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). (258 aa)

Predicted Functional Partners:

TRMT12

0.748

LCMT2

0.688

TRMT5

0.675

TYW1

0.666

UTP23

0.483

TYW5

0.457

ENSPPYP00000022731

0.435

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPPYP00000022731	LCMT2	ENSPPYP00000022731	ENSPPYP00000007263	annotation not available	Leucine carboxyl methyltransferase 2.	0.426
ENSPPYP00000022731	TRMT12	ENSPPYP00000022731	ENSPPYP00000021167	annotation not available	tRNA methyltransferase 12 homolog.	0.418
ENSPPYP00000022731	TRMT5	ENSPPYP00000022731	ENSPPYP00000006679	annotation not available	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	0.501
ENSPPYP00000022731	TYW1	ENSPPYP00000022731	ENSPPYP00000019631	annotation not available	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity); Belongs to the TYW1 family.	0.426
ENSPPYP00000022731	TYW3	ENSPPYP00000022731	ENSPPYP00000001435	annotation not available	tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).	0.435
LCMT2	ENSPPYP00000022731	ENSPPYP00000007263	ENSPPYP00000022731	Leucine carboxyl methyltransferase 2.	annotation not available	0.426
LCMT2	TRMT12	ENSPPYP00000007263	ENSPPYP00000021167	Leucine carboxyl methyltransferase 2.	tRNA methyltransferase 12 homolog.	0.725
LCMT2	TRMT5	ENSPPYP00000007263	ENSPPYP00000006679	Leucine carboxyl methyltransferase 2.	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	0.597
LCMT2	TYW1	ENSPPYP00000007263	ENSPPYP00000019631	Leucine carboxyl methyltransferase 2.	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity); Belongs to the TYW1 family.	0.530
LCMT2	TYW3	ENSPPYP00000007263	ENSPPYP00000001435	Leucine carboxyl methyltransferase 2.	tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).	0.688
LCMT2	TYW5	ENSPPYP00000007263	ENSPPYP00000024066	Leucine carboxyl methyltransferase 2.	TYW5 isoform 2.	0.584
TRMT12	ENSPPYP00000022731	ENSPPYP00000021167	ENSPPYP00000022731	tRNA methyltransferase 12 homolog.	annotation not available	0.418
TRMT12	LCMT2	ENSPPYP00000021167	ENSPPYP00000007263	tRNA methyltransferase 12 homolog.	Leucine carboxyl methyltransferase 2.	0.725
TRMT12	TRMT5	ENSPPYP00000021167	ENSPPYP00000006679	tRNA methyltransferase 12 homolog.	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	0.579
TRMT12	TYW1	ENSPPYP00000021167	ENSPPYP00000019631	tRNA methyltransferase 12 homolog.	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity); Belongs to the TYW1 family.	0.612
TRMT12	TYW3	ENSPPYP00000021167	ENSPPYP00000001435	tRNA methyltransferase 12 homolog.	tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).	0.748
TRMT12	TYW5	ENSPPYP00000021167	ENSPPYP00000024066	tRNA methyltransferase 12 homolog.	TYW5 isoform 2.	0.654
TRMT5	ENSPPYP00000022731	ENSPPYP00000006679	ENSPPYP00000022731	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	annotation not available	0.501
TRMT5	LCMT2	ENSPPYP00000006679	ENSPPYP00000007263	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	Leucine carboxyl methyltransferase 2.	0.597
TRMT5	TRMT12	ENSPPYP00000006679	ENSPPYP00000021167	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	tRNA methyltransferase 12 homolog.	0.579

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