node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CR201_G0015089 | CR201_G0053298 | ENSPPYP00000008406 | ENSPPYP00000002312 | TRADD isoform 2. | MIB2 isoform 16. | 0.887 |
CR201_G0015089 | FADD | ENSPPYP00000008406 | ENSPPYP00000003427 | TRADD isoform 2. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.999 |
CR201_G0015089 | SYNGR1 | ENSPPYP00000008406 | ENSPPYP00000013210 | TRADD isoform 2. | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. | 0.697 |
CR201_G0015089 | TNNI3K | ENSPPYP00000008406 | ENSPPYP00000001439 | TRADD isoform 2. | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. | 0.526 |
CR201_G0015089 | TRAF6 | ENSPPYP00000008406 | ENSPPYP00000003845 | TRADD isoform 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.902 |
CR201_G0053298 | CR201_G0015089 | ENSPPYP00000002312 | ENSPPYP00000008406 | MIB2 isoform 16. | TRADD isoform 2. | 0.887 |
CR201_G0053298 | FADD | ENSPPYP00000002312 | ENSPPYP00000003427 | MIB2 isoform 16. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.548 |
CR201_G0053298 | TNNI3K | ENSPPYP00000002312 | ENSPPYP00000001439 | MIB2 isoform 16. | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. | 0.548 |
CR201_G0053298 | TRAF6 | ENSPPYP00000002312 | ENSPPYP00000003845 | MIB2 isoform 16. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.647 |
DNAJC27 | GNPDA2 | ENSPPYP00000014064 | ENSPPYP00000016425 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Glucosamine-6-phosphate isomerase. | 0.456 |
DNAJC27 | SEC16B | ENSPPYP00000014064 | ENSPPYP00000000549 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. | 0.497 |
DNAJC27 | TNNI3K | ENSPPYP00000014064 | ENSPPYP00000001439 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. | 0.502 |
FADD | CR201_G0015089 | ENSPPYP00000003427 | ENSPPYP00000008406 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TRADD isoform 2. | 0.999 |
FADD | CR201_G0053298 | ENSPPYP00000003427 | ENSPPYP00000002312 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | MIB2 isoform 16. | 0.548 |
FADD | MAP2K4 | ENSPPYP00000003427 | ENSPPYP00000023632 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. | 0.432 |
FADD | SYNGR1 | ENSPPYP00000003427 | ENSPPYP00000013210 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. | 0.589 |
FADD | TNNI3K | ENSPPYP00000003427 | ENSPPYP00000001439 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. | 0.515 |
FADD | TRAF6 | ENSPPYP00000003427 | ENSPPYP00000003845 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.757 |
GNPDA2 | DNAJC27 | ENSPPYP00000016425 | ENSPPYP00000014064 | Glucosamine-6-phosphate isomerase. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling. | 0.456 |
GNPDA2 | SEC16B | ENSPPYP00000016425 | ENSPPYP00000000549 | Glucosamine-6-phosphate isomerase. | Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. | 0.680 |