DIRAS3 protein (Pongo abelii) - STRING interaction network

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Score

DIRAS3

DIRAS family GTPase 3. (229 aa)

Predicted Functional Partners:

ITSN2

0.815

PIK3CB

0.798

ITSN1

0.689

RAPGEF4

0.615

MST1R

0.568

MET

0.568

NF1

0.539

ERBB3

0.526

RAF1

0.525

BRAF

0.525

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	DIRAS3	ENSPPYP00000020265	ENSPPYP00000001458	BRAF isoform 1.	DIRAS family GTPase 3.	0.525
BRAF	ITSN2	ENSPPYP00000020265	ENSPPYP00000014069	BRAF isoform 1.	ITSN2 isoform 3.	0.447
BRAF	NF1	ENSPPYP00000020265	ENSPPYP00000009159	BRAF isoform 1.	NF1 isoform 6.	0.701
BRAF	PIK3CB	ENSPPYP00000020265	ENSPPYP00000015827	BRAF isoform 1.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.417
BRAF	RAF1	ENSPPYP00000020265	ENSPPYP00000014975	BRAF isoform 1.	RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...]	0.998
BRAF	RAPGEF4	ENSPPYP00000020265	ENSPPYP00000014442	BRAF isoform 1.	Rap guanine nucleotide exchange factor 4.	0.517
DIRAS3	BRAF	ENSPPYP00000001458	ENSPPYP00000020265	DIRAS family GTPase 3.	BRAF isoform 1.	0.525
DIRAS3	ERBB3	ENSPPYP00000001458	ENSPPYP00000005288	DIRAS family GTPase 3.	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	0.526
DIRAS3	ITSN1	ENSPPYP00000001458	ENSPPYP00000012707	DIRAS family GTPase 3.	ITSN1 isoform 4.	0.689
DIRAS3	ITSN2	ENSPPYP00000001458	ENSPPYP00000014069	DIRAS family GTPase 3.	ITSN2 isoform 3.	0.815
DIRAS3	MET	ENSPPYP00000001458	ENSPPYP00000020106	DIRAS family GTPase 3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.568
DIRAS3	MST1R	ENSPPYP00000001458	ENSPPYP00000015506	DIRAS family GTPase 3.	MST1R isoform 1.	0.568
DIRAS3	NF1	ENSPPYP00000001458	ENSPPYP00000009159	DIRAS family GTPase 3.	NF1 isoform 6.	0.539
DIRAS3	PIK3CB	ENSPPYP00000001458	ENSPPYP00000015827	DIRAS family GTPase 3.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.798
DIRAS3	RAF1	ENSPPYP00000001458	ENSPPYP00000014975	DIRAS family GTPase 3.	RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...]	0.525
DIRAS3	RAPGEF4	ENSPPYP00000001458	ENSPPYP00000014442	DIRAS family GTPase 3.	Rap guanine nucleotide exchange factor 4.	0.615
ERBB3	DIRAS3	ENSPPYP00000005288	ENSPPYP00000001458	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	DIRAS family GTPase 3.	0.526
ERBB3	ITSN2	ENSPPYP00000005288	ENSPPYP00000014069	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	ITSN2 isoform 3.	0.472
ERBB3	MET	ENSPPYP00000005288	ENSPPYP00000020106	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.986
ERBB3	MST1R	ENSPPYP00000005288	ENSPPYP00000015506	Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.	MST1R isoform 1.	0.743