Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIRAS3DIRAS family GTPase 3. (229 aa)    
Predicted Functional Partners:
AKR1C8P
Prostaglandin F synthase 1-like isoform X1.
    
 
 0.898
LRRC17
LRRC17 isoform 2.
    
 0.841
PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
    
 0.798
ENSPPYP00000002371
Aldo-keto reductase family 1 member C1 homolog.
    
 
 0.759
RARRES2
Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...]
      
 0.741
RNF19B
RBR-type E3 ubiquitin transferase.
    
   0.736
LEUTX
LEUTX isoform 2.
      
 0.685
RAPGEF4
Rap guanine nucleotide exchange factor 4.
   
 0.665
HEY2
Hes related family bHLH transcription factor with YRPW motif 2.
    
 
 0.610
LCAT
Phosphatidylcholine-sterol acyltransferase.
      
 0.604
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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