INSL5 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0001684	INSL5	ENSPPYP00000021546	ENSPPYP00000001471	RLN2 isoform 1.	INSL5 isoform 1.	0.928
CR201_G0001684	RLN3	ENSPPYP00000021546	ENSPPYP00000010796	RLN2 isoform 1.	RLN3 isoform 1.	0.955
CR201_G0001684	RXFP1	ENSPPYP00000021546	ENSPPYP00000016938	RLN2 isoform 1.	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).	0.959
CR201_G0001684	RXFP2	ENSPPYP00000021546	ENSPPYP00000005990	RLN2 isoform 1.	RXFP2 isoform 1.	0.959
CR201_G0001684	RXFP3	ENSPPYP00000021546	ENSPPYP00000017183	RLN2 isoform 1.	RXFP3 isoform 1.	0.919
CR201_G0001684	RXFP4	ENSPPYP00000021546	ENSPPYP00000000852	RLN2 isoform 1.	RXFP4 isoform 1.	0.919
GNB1	GNG4	ENSPPYP00000002307	ENSPPYP00000000094	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.972
GNB1	INSL5	ENSPPYP00000002307	ENSPPYP00000001471	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	INSL5 isoform 1.	0.532
GNB1	RLN3	ENSPPYP00000002307	ENSPPYP00000010796	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	RLN3 isoform 1.	0.628
GNB1	RXFP1	ENSPPYP00000002307	ENSPPYP00000016938	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).	0.780
GNB1	RXFP4	ENSPPYP00000002307	ENSPPYP00000000852	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	RXFP4 isoform 1.	0.563
GNG4	GNB1	ENSPPYP00000000094	ENSPPYP00000002307	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.972
GNG4	INSL5	ENSPPYP00000000094	ENSPPYP00000001471	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	INSL5 isoform 1.	0.461
GNG4	RLN3	ENSPPYP00000000094	ENSPPYP00000010796	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	RLN3 isoform 1.	0.525
GNG4	RXFP1	ENSPPYP00000000094	ENSPPYP00000016938	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).	0.469
INSL5	CR201_G0001684	ENSPPYP00000001471	ENSPPYP00000021546	INSL5 isoform 1.	RLN2 isoform 1.	0.928
INSL5	GNB1	ENSPPYP00000001471	ENSPPYP00000002307	INSL5 isoform 1.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.532
INSL5	GNG4	ENSPPYP00000001471	ENSPPYP00000000094	INSL5 isoform 1.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.461
INSL5	INSL6	ENSPPYP00000001471	ENSPPYP00000021550	INSL5 isoform 1.	Insulin-like peptide INSL6; May have a role in sperm development and fertilization. Belongs to the insulin family.	0.520
INSL5	RLN3	ENSPPYP00000001471	ENSPPYP00000010796	INSL5 isoform 1.	RLN3 isoform 1.	0.990