LEPR protein (Pongo abelii) - STRING interaction network

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[Homology]

Score

LEPR

Leptin receptor. (1165 aa)

Predicted Functional Partners:

LEP

0.996

JAK2

0.993

SOCS3

0.978

STAT3

0.968

PRLR

0.955

GHR

0.930

EPOR

0.909

MPL

0.901

CSF3R

0.900

PRL

0.866

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF3R	EPOR	ENSPPYP00000001772	ENSPPYP00000024078	CSF3R isoform 3.	Erythropoietin receptor; Receptor for erythropoietin.	0.928
CSF3R	GHR	ENSPPYP00000001772	ENSPPYP00000017241	CSF3R isoform 3.	Growth hormone receptor.	0.902
CSF3R	JAK2	ENSPPYP00000001772	ENSPPYP00000021551	CSF3R isoform 3.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.954
CSF3R	LEP	ENSPPYP00000001772	ENSPPYP00000020162	CSF3R isoform 3.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.655
CSF3R	LEPR	ENSPPYP00000001772	ENSPPYP00000001479	CSF3R isoform 3.	Leptin receptor.	0.900
CSF3R	MPL	ENSPPYP00000001772	ENSPPYP00000001679	CSF3R isoform 3.	MPL isoform 2.	0.925
CSF3R	PRL	ENSPPYP00000001772	ENSPPYP00000018197	CSF3R isoform 3.	PRL isoform 1.	0.650
CSF3R	PRLR	ENSPPYP00000001772	ENSPPYP00000017194	CSF3R isoform 3.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.904
CSF3R	SOCS3	ENSPPYP00000001772	ENSPPYP00000009756	CSF3R isoform 3.	Suppressor of cytokine signaling 3.	0.850
CSF3R	STAT3	ENSPPYP00000001772	ENSPPYP00000009437	CSF3R isoform 3.	Signal transducer and activator of transcription.	0.817
EPOR	CSF3R	ENSPPYP00000024078	ENSPPYP00000001772	Erythropoietin receptor; Receptor for erythropoietin.	CSF3R isoform 3.	0.928
EPOR	GHR	ENSPPYP00000024078	ENSPPYP00000017241	Erythropoietin receptor; Receptor for erythropoietin.	Growth hormone receptor.	0.912
EPOR	JAK2	ENSPPYP00000024078	ENSPPYP00000021551	Erythropoietin receptor; Receptor for erythropoietin.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.999
EPOR	LEP	ENSPPYP00000024078	ENSPPYP00000020162	Erythropoietin receptor; Receptor for erythropoietin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.806
EPOR	LEPR	ENSPPYP00000024078	ENSPPYP00000001479	Erythropoietin receptor; Receptor for erythropoietin.	Leptin receptor.	0.909
EPOR	MPL	ENSPPYP00000024078	ENSPPYP00000001679	Erythropoietin receptor; Receptor for erythropoietin.	MPL isoform 2.	0.910
EPOR	PRL	ENSPPYP00000024078	ENSPPYP00000018197	Erythropoietin receptor; Receptor for erythropoietin.	PRL isoform 1.	0.673
EPOR	PRLR	ENSPPYP00000024078	ENSPPYP00000017194	Erythropoietin receptor; Receptor for erythropoietin.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.907
EPOR	SOCS3	ENSPPYP00000024078	ENSPPYP00000009756	Erythropoietin receptor; Receptor for erythropoietin.	Suppressor of cytokine signaling 3.	0.583
EPOR	STAT3	ENSPPYP00000024078	ENSPPYP00000009437	Erythropoietin receptor; Receptor for erythropoietin.	Signal transducer and activator of transcription.	0.844