UBE2U protein (Pongo abelii) - STRING interaction network

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UBE2U

UBE2U isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (226 aa)

Predicted Functional Partners:

UBOX5

0.898

TRIP12

0.805

RAD18

0.790

ENSPPYP00000012086

0.780

TMEM189-UBE2V1

0.780

CR201_G0012323

0.776

PCNA

0.774

UBR1

0.765

MVB12A

0.736

SUMO1

0.726

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0012323	ENSPPYP00000012086	ENSPPYP00000009999	ENSPPYP00000012086	UBE2Z isoform 1.	annotation not available	0.736
CR201_G0012323	PCNA	ENSPPYP00000009999	ENSPPYP00000012059	UBE2Z isoform 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.438
CR201_G0012323	RAD18	ENSPPYP00000009999	ENSPPYP00000015305	UBE2Z isoform 1.	RAD18 isoform 2.	0.401
CR201_G0012323	SUMO1	ENSPPYP00000009999	ENSPPYP00000014619	UBE2Z isoform 1.	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...]	0.427
CR201_G0012323	TMEM189-UBE2V1	ENSPPYP00000009999	ENSPPYP00000012429	UBE2Z isoform 1.	Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...]	0.754
CR201_G0012323	TRIP12	ENSPPYP00000009999	ENSPPYP00000014809	UBE2Z isoform 1.	TRIP12 isoform 4.	0.678
CR201_G0012323	UBE2U	ENSPPYP00000009999	ENSPPYP00000001485	UBE2Z isoform 1.	UBE2U isoform 1; Belongs to the ubiquitin-conjugating enzyme family.	0.776
CR201_G0012323	UBOX5	ENSPPYP00000009999	ENSPPYP00000012091	UBE2Z isoform 1.	UBOX5 isoform 2.	0.676
ENSPPYP00000012086	CR201_G0012323	ENSPPYP00000012086	ENSPPYP00000009999	annotation not available	UBE2Z isoform 1.	0.736
ENSPPYP00000012086	PCNA	ENSPPYP00000012086	ENSPPYP00000012059	annotation not available	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.767
ENSPPYP00000012086	RAD18	ENSPPYP00000012086	ENSPPYP00000015305	annotation not available	RAD18 isoform 2.	0.632
ENSPPYP00000012086	SUMO1	ENSPPYP00000012086	ENSPPYP00000014619	annotation not available	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...]	0.447
ENSPPYP00000012086	TMEM189-UBE2V1	ENSPPYP00000012086	ENSPPYP00000012429	annotation not available	Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...]	0.981
ENSPPYP00000012086	TRIP12	ENSPPYP00000012086	ENSPPYP00000014809	annotation not available	TRIP12 isoform 4.	0.503
ENSPPYP00000012086	UBE2U	ENSPPYP00000012086	ENSPPYP00000001485	annotation not available	UBE2U isoform 1; Belongs to the ubiquitin-conjugating enzyme family.	0.780
MVB12A	UBE2U	ENSPPYP00000010885	ENSPPYP00000001485	Multivesicular body subunit 12A.	UBE2U isoform 1; Belongs to the ubiquitin-conjugating enzyme family.	0.736
PCNA	CR201_G0012323	ENSPPYP00000012059	ENSPPYP00000009999	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	UBE2Z isoform 1.	0.438
PCNA	ENSPPYP00000012086	ENSPPYP00000012059	ENSPPYP00000012086	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	annotation not available	0.767
PCNA	RAD18	ENSPPYP00000012059	ENSPPYP00000015305	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	RAD18 isoform 2.	0.988
PCNA	SUMO1	ENSPPYP00000012059	ENSPPYP00000014619	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...]	0.787