Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (502 aa)    
Predicted Functional Partners:
CYP3A4
Cytochrome P450 family 3 subfamily A member 4.
  
0.948
CR201_G0037528
CYP4F3 isoform 2; Belongs to the cytochrome P450 family.
  
0.945
CR201_G0037513
CYP4F2 isoform 1; Belongs to the cytochrome P450 family.
  
0.945
CYP1A2
Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]
  
 
0.931
CYP2U1
CYP2U1 isoform 1; Belongs to the cytochrome P450 family.
  
 
 
0.931
CYP2E1
CYP2E1 isoform 1; Belongs to the cytochrome P450 family.
  
 
0.925
CYP2C8
CYP2C8 isoform 4; Belongs to the cytochrome P450 family.
  
 
 
0.919
ENSPPYP00000002903
Cytochrome P450 family 2 subfamily C polypeptide 9.
  
 
 
0.918
CYP2B6
CYP2B6 isoform 1; Belongs to the cytochrome P450 family.
  
 
 
0.917
ALOX5
ALOX5 isoform 2.
   
 0.910
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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