HOOK1 protein (Pongo abelii) - STRING interaction network

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[Homology]

Score

HOOK1

Hook microtubule tethering protein 1. (728 aa)

Predicted Functional Partners:

AKTIP

0.970

HOOK3

0.915

FAM160A2

0.898

CDK4

0.763

FAM160B1

0.755

PRTFDC1

0.749

FAM160A1

0.716

VPS18

0.713

TAF1A

0.707

LRGUK

0.677

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKTIP	FAM160A1	ENSPPYP00000008302	ENSPPYP00000016898	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	Family with sequence similarity 160 member A1.	0.974
AKTIP	FAM160A2	ENSPPYP00000008302	ENSPPYP00000004071	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family.	0.995
AKTIP	FAM160B1	ENSPPYP00000008302	ENSPPYP00000003124	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	FAM160B1 isoform 2.	0.573
AKTIP	HOOK1	ENSPPYP00000008302	ENSPPYP00000001508	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	Hook microtubule tethering protein 1.	0.970
AKTIP	HOOK3	ENSPPYP00000008302	ENSPPYP00000020818	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	Protein Hook homolog 3 isoform X1.	0.951
AKTIP	VPS18	ENSPPYP00000008302	ENSPPYP00000007209	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	VPS18 core subunit of CORVET and HOPS complexes.	0.455
CDK4	HOOK1	ENSPPYP00000005360	ENSPPYP00000001508	CDK4 isoform 2; Belongs to the protein kinase superfamily.	Hook microtubule tethering protein 1.	0.763
FAM160A1	AKTIP	ENSPPYP00000016898	ENSPPYP00000008302	Family with sequence similarity 160 member A1.	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	0.974
FAM160A1	FAM160B1	ENSPPYP00000016898	ENSPPYP00000003124	Family with sequence similarity 160 member A1.	FAM160B1 isoform 2.	0.658
FAM160A1	HOOK1	ENSPPYP00000016898	ENSPPYP00000001508	Family with sequence similarity 160 member A1.	Hook microtubule tethering protein 1.	0.716
FAM160A1	HOOK3	ENSPPYP00000016898	ENSPPYP00000020818	Family with sequence similarity 160 member A1.	Protein Hook homolog 3 isoform X1.	0.969
FAM160A2	AKTIP	ENSPPYP00000004071	ENSPPYP00000008302	FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family.	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	0.995
FAM160A2	HOOK1	ENSPPYP00000004071	ENSPPYP00000001508	FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family.	Hook microtubule tethering protein 1.	0.898
FAM160A2	HOOK3	ENSPPYP00000004071	ENSPPYP00000020818	FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family.	Protein Hook homolog 3 isoform X1.	0.955
FAM160B1	AKTIP	ENSPPYP00000003124	ENSPPYP00000008302	FAM160B1 isoform 2.	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	0.573
FAM160B1	FAM160A1	ENSPPYP00000003124	ENSPPYP00000016898	FAM160B1 isoform 2.	Family with sequence similarity 160 member A1.	0.658
FAM160B1	HOOK1	ENSPPYP00000003124	ENSPPYP00000001508	FAM160B1 isoform 2.	Hook microtubule tethering protein 1.	0.755
FAM160B1	HOOK3	ENSPPYP00000003124	ENSPPYP00000020818	FAM160B1 isoform 2.	Protein Hook homolog 3 isoform X1.	0.611
HOOK1	AKTIP	ENSPPYP00000001508	ENSPPYP00000008302	Hook microtubule tethering protein 1.	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	0.970
HOOK1	CDK4	ENSPPYP00000001508	ENSPPYP00000005360	Hook microtubule tethering protein 1.	CDK4 isoform 2; Belongs to the protein kinase superfamily.	0.763