HOOK1 protein (Pongo abelii) - STRING interaction network

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Score

HOOK1

Hook microtubule tethering protein 1. (728 aa)

Predicted Functional Partners:

AKTIP

0.936

HOOK3

0.879

FAM160A2

0.837

CLN3

0.707

RAB11A

0.634

CR201_G0031330

0.583

BICD2

0.537

DYNC1LI1

0.534

CR201_G0047562

0.528

FAM160B1

0.518

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKTIP	FAM160A2	ENSPPYP00000008302	ENSPPYP00000004071	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family.	0.985
AKTIP	FAM160B1	ENSPPYP00000008302	ENSPPYP00000003124	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	FAM160B1 isoform 2.	0.450
AKTIP	HOOK1	ENSPPYP00000008302	ENSPPYP00000001508	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	Hook microtubule tethering protein 1.	0.936
AKTIP	HOOK3	ENSPPYP00000008302	ENSPPYP00000020818	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	Protein Hook homolog 3 isoform X1.	0.905
BICD2	DYNC1LI1	ENSPPYP00000021721	ENSPPYP00000015707	BICD cargo adaptor 2.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.998
BICD2	HOOK1	ENSPPYP00000021721	ENSPPYP00000001508	BICD cargo adaptor 2.	Hook microtubule tethering protein 1.	0.537
BICD2	HOOK3	ENSPPYP00000021721	ENSPPYP00000020818	BICD cargo adaptor 2.	Protein Hook homolog 3 isoform X1.	0.702
CLN3	HOOK1	ENSPPYP00000008173	ENSPPYP00000001508	Battenin.	Hook microtubule tethering protein 1.	0.707
CLN3	HOOK3	ENSPPYP00000008173	ENSPPYP00000020818	Battenin.	Protein Hook homolog 3 isoform X1.	0.504
CLN3	RAB11A	ENSPPYP00000008173	ENSPPYP00000007454	Battenin.	Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...]	0.409
CR201_G0031330	DYNC1LI1	ENSPPYP00000003589	ENSPPYP00000015707	CCDC88B isoform 9.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.438
CR201_G0031330	HOOK1	ENSPPYP00000003589	ENSPPYP00000001508	CCDC88B isoform 9.	Hook microtubule tethering protein 1.	0.583
CR201_G0047562	HOOK1	ENSPPYP00000013406	ENSPPYP00000001508	RIMBP3C isoform 2.	Hook microtubule tethering protein 1.	0.528
DYNC1LI1	BICD2	ENSPPYP00000015707	ENSPPYP00000021721	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	BICD cargo adaptor 2.	0.998
DYNC1LI1	CR201_G0031330	ENSPPYP00000015707	ENSPPYP00000003589	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	CCDC88B isoform 9.	0.438
DYNC1LI1	HOOK1	ENSPPYP00000015707	ENSPPYP00000001508	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	Hook microtubule tethering protein 1.	0.534
DYNC1LI1	HOOK3	ENSPPYP00000015707	ENSPPYP00000020818	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	Protein Hook homolog 3 isoform X1.	0.944
DYNC1LI1	RAB11A	ENSPPYP00000015707	ENSPPYP00000007454	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...]	0.468
FAM160A2	AKTIP	ENSPPYP00000004071	ENSPPYP00000008302	FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family.	AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).	0.985
FAM160A2	HOOK1	ENSPPYP00000004071	ENSPPYP00000001508	FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity); Belongs to the UPF0518 family.	Hook microtubule tethering protein 1.	0.837