Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
NDC1Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity); Belongs to the NDC1 family. (673 aa)    
Predicted Functional Partners:
NUP93
Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling; Belongs to the nucleoporin interacting component (NIC) family.
   
 0.995
AAAS
AAAS isoform 6.
   
 0.991
NUP188
NUP188 isoform 1.
   
 0.989
NUP35
Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.
   
 0.988
NUP155
NUP155 isoform 1.
   
 0.986
NUP98
NUP98 isoform 2.
   
 0.985
NUP85
Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).
   
 0.985
NUP153
NUP153 isoform 3.
    
 0.981
NUP43
NUP43 isoform 1.
   
 0.981
NUP88
NUP88 isoform 1.
    
 0.979
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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