LRP8 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LRP8

LRP8 isoform 1. (955 aa)

Predicted Functional Partners:

RELN

0.980

APOE

0.930

DAB1

0.851

LRPAP1

0.827

PCSK9

0.744

VLDLR

0.736

APOH

0.712

CLU

0.710

APBB1

0.705

SNX17

0.702

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1	APOE	ENSPPYP00000004064	ENSPPYP00000011298	APBB1 isoform 1.	Apolipoprotein E.	0.474
APBB1	DAB1	ENSPPYP00000004064	ENSPPYP00000001515	APBB1 isoform 1.	DAB adaptor protein 1.	0.405
APBB1	LRP8	ENSPPYP00000004064	ENSPPYP00000001551	APBB1 isoform 1.	LRP8 isoform 1.	0.705
APBB1	SNX17	ENSPPYP00000004064	ENSPPYP00000014016	APBB1 isoform 1.	Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).	0.481
APBB1	VLDLR	ENSPPYP00000004064	ENSPPYP00000021562	APBB1 isoform 1.	Very low density lipoprotein receptor.	0.542
APOE	APBB1	ENSPPYP00000011298	ENSPPYP00000004064	Apolipoprotein E.	APBB1 isoform 1.	0.474
APOE	APOH	ENSPPYP00000011298	ENSPPYP00000009611	Apolipoprotein E.	APOH isoform 1.	0.702
APOE	CLU	ENSPPYP00000011298	ENSPPYP00000020696	Apolipoprotein E.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.938
APOE	LRP8	ENSPPYP00000011298	ENSPPYP00000001551	Apolipoprotein E.	LRP8 isoform 1.	0.930
APOE	RELN	ENSPPYP00000011298	ENSPPYP00000020048	Apolipoprotein E.	RELN isoform 2.	0.534
APOE	VLDLR	ENSPPYP00000011298	ENSPPYP00000021562	Apolipoprotein E.	Very low density lipoprotein receptor.	0.958
APOH	APOE	ENSPPYP00000009611	ENSPPYP00000011298	APOH isoform 1.	Apolipoprotein E.	0.702
APOH	CLU	ENSPPYP00000009611	ENSPPYP00000020696	APOH isoform 1.	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	0.682
APOH	LRP8	ENSPPYP00000009611	ENSPPYP00000001551	APOH isoform 1.	LRP8 isoform 1.	0.712
APOH	VLDLR	ENSPPYP00000009611	ENSPPYP00000021562	APOH isoform 1.	Very low density lipoprotein receptor.	0.585
CLU	APOE	ENSPPYP00000020696	ENSPPYP00000011298	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	Apolipoprotein E.	0.938
CLU	APOH	ENSPPYP00000020696	ENSPPYP00000009611	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	APOH isoform 1.	0.682
CLU	LRP8	ENSPPYP00000020696	ENSPPYP00000001551	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	LRP8 isoform 1.	0.710
CLU	VLDLR	ENSPPYP00000020696	ENSPPYP00000021562	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	Very low density lipoprotein receptor.	0.803
DAB1	APBB1	ENSPPYP00000001515	ENSPPYP00000004064	DAB adaptor protein 1.	APBB1 isoform 1.	0.405