ZYG11B protein (Pongo abelii) - STRING interaction network

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ZYG11B

Zyg-11 family member B, cell cycle regulator. (744 aa)

Predicted Functional Partners:

CUL2

0.907

ELOC

0.811

ENSPPYP00000023677

0.811

RBX1

0.775

ENSPPYP00000004644

0.729

ELOB

0.729

VHL

0.649

ZER1

0.637

CR201_G0029860

0.603

APPBP2

0.593

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPBP2	CUL2	ENSPPYP00000009567	ENSPPYP00000022294	Amyloid beta precursor protein binding protein 2.	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	0.875
APPBP2	ELOB	ENSPPYP00000009567	ENSPPYP00000007934	Amyloid beta precursor protein binding protein 2.	ELOB isoform 1.	0.505
APPBP2	ELOC	ENSPPYP00000009567	ENSPPYP00000020952	Amyloid beta precursor protein binding protein 2.	ELOC isoform 10; Belongs to the SKP1 family.	0.735
APPBP2	ENSPPYP00000004644	ENSPPYP00000009567	ENSPPYP00000004644	Amyloid beta precursor protein binding protein 2.	annotation not available	0.505
APPBP2	ENSPPYP00000023677	ENSPPYP00000009567	ENSPPYP00000023677	Amyloid beta precursor protein binding protein 2.	annotation not available	0.735
APPBP2	RBX1	ENSPPYP00000009567	ENSPPYP00000013235	Amyloid beta precursor protein binding protein 2.	RBX1 isoform 1.	0.850
APPBP2	ZER1	ENSPPYP00000009567	ENSPPYP00000022035	Amyloid beta precursor protein binding protein 2.	Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation; Belongs to the [...]	0.589
APPBP2	ZYG11B	ENSPPYP00000009567	ENSPPYP00000001561	Amyloid beta precursor protein binding protein 2.	Zyg-11 family member B, cell cycle regulator.	0.593
CR201_G0029860	ZER1	ENSPPYP00000023718	ENSPPYP00000022035	ZNF701 isoform 4.	Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation; Belongs to the [...]	0.823
CR201_G0029860	ZYG11B	ENSPPYP00000023718	ENSPPYP00000001561	ZNF701 isoform 4.	Zyg-11 family member B, cell cycle regulator.	0.603
CUL2	APPBP2	ENSPPYP00000022294	ENSPPYP00000009567	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	Amyloid beta precursor protein binding protein 2.	0.875
CUL2	ELOB	ENSPPYP00000022294	ENSPPYP00000007934	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	ELOB isoform 1.	0.998
CUL2	ELOC	ENSPPYP00000022294	ENSPPYP00000020952	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	ELOC isoform 10; Belongs to the SKP1 family.	0.999
CUL2	ENSPPYP00000004644	ENSPPYP00000022294	ENSPPYP00000004644	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	annotation not available	0.992
CUL2	ENSPPYP00000023677	ENSPPYP00000022294	ENSPPYP00000023677	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	annotation not available	0.997
CUL2	RBX1	ENSPPYP00000022294	ENSPPYP00000013235	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	RBX1 isoform 1.	0.999
CUL2	VHL	ENSPPYP00000022294	ENSPPYP00000015275	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	VHL isoform 1.	0.995
CUL2	ZER1	ENSPPYP00000022294	ENSPPYP00000022035	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation; Belongs to the [...]	0.910
CUL2	ZYG11B	ENSPPYP00000022294	ENSPPYP00000001561	Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...]	Zyg-11 family member B, cell cycle regulator.	0.907
ELOB	APPBP2	ENSPPYP00000007934	ENSPPYP00000009567	ELOB isoform 1.	Amyloid beta precursor protein binding protein 2.	0.505