NRDC protein (Pongo abelii) - STRING interaction network

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NRDC

Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. (1219 aa)

Predicted Functional Partners:

IDE

0.816

INS-IGF2

0.756

TREH

0.730

DNPEP

0.724

PTBP3

0.697

OXNAD1

0.691

PSMB10

0.611

THOP1

0.608

PSME3

0.599

CCDC130

0.585

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC130	NRDC	ENSPPYP00000011833	ENSPPYP00000001576	CCDC130 isoform 1.	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	0.585
DNPEP	IDE	ENSPPYP00000014757	ENSPPYP00000002877	Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity).	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.404
DNPEP	NRDC	ENSPPYP00000014757	ENSPPYP00000001576	Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity).	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	0.724
IDE	DNPEP	ENSPPYP00000002877	ENSPPYP00000014757	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity).	0.404
IDE	INS-IGF2	ENSPPYP00000002877	ENSPPYP00000003393	Insulin degrading enzyme; Belongs to the peptidase M16 family.	INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.970
IDE	NRDC	ENSPPYP00000002877	ENSPPYP00000001576	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	0.816
IDE	THOP1	ENSPPYP00000002877	ENSPPYP00000010500	Insulin degrading enzyme; Belongs to the peptidase M16 family.	THOP1 isoform 1.	0.527
IDE	TREH	ENSPPYP00000002877	ENSPPYP00000004514	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Trehalase.	0.475
INS-IGF2	IDE	ENSPPYP00000003393	ENSPPYP00000002877	INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.970
INS-IGF2	NRDC	ENSPPYP00000003393	ENSPPYP00000001576	INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	0.756
NRDC	CCDC130	ENSPPYP00000001576	ENSPPYP00000011833	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	CCDC130 isoform 1.	0.585
NRDC	DNPEP	ENSPPYP00000001576	ENSPPYP00000014757	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity).	0.724
NRDC	IDE	ENSPPYP00000001576	ENSPPYP00000002877	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.816
NRDC	INS-IGF2	ENSPPYP00000001576	ENSPPYP00000003393	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.756
NRDC	OXNAD1	ENSPPYP00000001576	ENSPPYP00000015753	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	Oxidoreductase NAD-binding domain-containing protein 1.	0.691
NRDC	PSMB10	ENSPPYP00000001576	ENSPPYP00000008443	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	Proteasome subunit beta.	0.611
NRDC	PSME3	ENSPPYP00000001576	ENSPPYP00000009413	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...]	0.599
NRDC	PTBP3	ENSPPYP00000001576	ENSPPYP00000021852	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	PTBP3 isoform 3.	0.697
NRDC	THOP1	ENSPPYP00000001576	ENSPPYP00000010500	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	THOP1 isoform 1.	0.608
NRDC	TREH	ENSPPYP00000001576	ENSPPYP00000004514	Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.	Trehalase.	0.730

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